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The IMPACCT Rapid Program prospectively evaluates medicines that are used on a day-to-day basis so that clinicians can make better decisions at the bedside.

Tired but smiling man with dark hair wearing blue buttoned shirt

Adult

Anti-depressants for depression in palliative care - series 49

Help us guide clinicians in their understanding of which antidepressant agent could be best suited for different palliative patient profiles. 

The assessment and management of depression can be challenging due to the symptoms and complications of advanced illnesses. To date, it is unclear if patients tolerate and receive actual benefit from antidepressants in real-world palliative care clinical practice, particularly when life expectancy is in the range of days to weeks. 

The series will compare the clinical benefits and harms of four commonly prescribed antidepressant agents in palliative care: mirtazapine, duloxetine, citalopram and escitalopram.

By collecting data for this series, you will be helping us to understand clinicians’ prescribing practices, as well as the harms and benefits of antidepressant use in the palliative care setting.

Get involved

learn more - read the series manual (pdf, 178kb)

collect data - download the case report form (pdf, 620kb)

Benzodiazepines for breathlessness - series 10

Benzodiazepines are sedative medications that are recommended for short-term use in the treatment of anxiety and insomnia.  For some time now, benzodiazepines are also routinely recommended and prescribed as adjuvant agents in the palliation of breathlessness. However, there is no evidence for or against benzodiazepines for the relief of breathlessness in people with advanced cancer and COPD. A systematic review highlighted that benzodiazepines cause more drowsiness as an adverse effect compared to placebo and suggested that benzodiazepines may be considered as a second- or third-line treatment when opioids and non-pharmacological measures have failed to control breathlessness.

This phase IV pharmacovigilance study is uniquely examining real clinical experience when palliative care patients receive benzodiazepines as part of their dyspnoea management.  This is very important data as it will not only enhance understanding of the reasons that clinicians choose to prescribe benzodiazepines but also examine the safety of the process. 

get involved

learn more - read the series manual (pdf, 149kb)

collect data - download the case report form (pdf, 303kb)

Fans for Breathlessness - series 55

Are you treating breathlessness using handheld fans?

Female holding a white handheld fan

Clinical trials suggest that hand-held fans can improve breathlessness-related outcomes, but evidence varies between measures and patient populations. There is limited guidance for patients and clinicians on how to use hand-held fans optimally, especially in relation to other strategies for breathlessness management. It therefore seems likely that practice varies between services and clinicians, with unknown implications for effectiveness.

Help us understand clinician practices regarding hand-held fans and their perceived benefits and adverse effects in everyday clinical settings

get involved

learn more - read the series manual (PDF, 225KB)

collect data - download the case report form (pdf, 217kb)

Intrathecal catheters for pain management - series 36

Doctor's gloved hands preparing patient for spinal anaesthesia

Pain is a common and distressing symptom in the palliative care patient population. Even with multimodal, multidisciplinary and patient-centred holistic care, there remains a group of patients in whom pain remains poorly managed, or for whom side effects of systemic medications significantly negatively impact quality of life.

Intrathecal drug delivery is an interventional pain management option that can be considered in this group. Smaller doses (compared with the oral or parenteral routes) of medication/s are delivered into the intrathecal space thereby aiming to maximise efficacy and minimise medication-related side effects such as constipation, nausea, vomiting and drowsiness.

There are several medications available for infusion into the intrathecal space including opioids, local anaesthetics, clonidine and baclofen.

Decision making around intrathecal catheter insertion and the associated medication and infusion system selection takes into consideration several factors including pain location and type, diagnosis and prognosis, patient preference and the availability of local resources and expertise.

The aim of this series is to explore the use, efficacy, complications and side-effect profile of intrathecal drug delivery in the management of patients with life-limiting illnesses.

Get involved

RAPID SERIES MANUAL - INTRATHECAL CATHETERS FOR PAIN MANAGEMENT SERIES 36 (pdf, 567KB)

CASE REPORT FORM - INTRATHECAL CATHETERS FOR PAIN MANAGEMENT SERIES 36 (PDF, 1648KB)

Medicinal cannabis in palliative care- series 19

Blister packs of capsules with cannabis leaf and oil with dropper

There is wide public interest in the role of medicinal cannabis in cancer care generally, and palliative care in particular. Despite this substantial interest, many clinicians in palliative care remain wary of prescribing medicinal cannabis. They cite concerns about the lack of evidence underpinning the role of medical cannabis, concerns about the potential for adverse effects and the unconventional way by which cannabis came to be listed as a medicine in many jurisdictions, including Australia. 

This series will address some of these concerns by establishing a significant database of real-time monitoring of patients prescribed cannabis who are receiving palliative care. These data will capture the benefits or effects, as well as adverse effects seen for patients. Specifically, all patients attending palliative care services who are prescribed medical cannabis for any indication will have a series of outcomes documented (1) at time of prescription, and (2) at subsequent standardised follow-up times. Outcomes of interest include evidence of effects upon symptoms such as pain, appetite, nausea, sleep and on overall quality of life. In addition, data will be collected around any evidence of adverse effects such as sedation, confusion and other potential side effects. The doses of cannabis and of other medications prescribed for symptom relief will be collected. 

This important study will enable prospective monitoring of a medication that is already available and where the evidence underpinning its use is limited. Australian palliative care services are uniquely placed to contribute to this real-time data monitoring and reporting project with potential to inform practice worldwide. 

get involved

learn more - read the series manual (pdf, 449kb)

Collect data - download the case Report Form (pdf, 530kb)

Melatonin for insomnia - series 39

Are you prescribing or administering melatonin to people in palliative care?

This series examines the use, efficacy and safety of prescription melatonin for the treatment of insomnia in people receiving palliative care.

Melatonin, secreted by the pineal gland, is a naturally occurring hormone that regulates circadian rhythm and the sleep-wake cycle in humans. Prescription melatonin is regarded as safe and is known to improve quality of sleep as well as morning alertness in people over the age of 55.

Help us collect data to improve the evidence that information best-practice clinical decision making about prescription melatonin in palliative care.

get involved

learn more - read the series manual (pdf, 138kb)

collect data - download the case report form (pdf, 342kb)

Mesothelioma-night sweats - series 44

Worried about your patients having night sweats? If you are administering NSAIDS, corticosteroids or paracetamol for night sweats, you can help improve our understanding of how to best manage this troubling symptom.

Night sweats are prevalent for people with advanced malignant mesothelioma and other cancers. They can cause significant sleep disturbance, excessive sleepiness and mood disturbances. This impacts cancer cachexia syndrome leading to a net decrease in the overall quality of life.

Few pharmacological therapies have been trialled in the management of night sweats in people with advanced cancer, including mesothelioma. Due to the lack of evidence, there are no specific pharmacological guidelines to inform how clinicians can best manage night sweats.

This series studies three classes of medications that are often prescribed to treat night sweats – NSAIDS Corticosteroids and paracetamol. There are therefore three separate case report forms for this series – choose the one that matches the medication that you are prescribing or administering.

get involved

learn more - read the series manual (PDF, 10KB)

collect data - download the case report FORM for nsaids (pdf, 398kb)

COLLECT DATA - DOWNLOAD THE CASE REPORT FORM FOR CORTICOSTEROIDS (PDF, 448KB)

COLLECT DATA - DOWNLOAD THE CASE REPORT FORM FOR PARACETAMOL (PDF, 398KB) 

Ondansetron for nausea and vomiting - series 48

Older man with grey hair and moustache in blue shirt with hand over mouth

Nausea is a common and distressing symptom for people with advanced illness. While nausea caused by chemotherapy and/or radiotherapy has been intensively studied and multiple medications, including ondansetron, have proven to be beneficial, it has not been effectively studied for people with non-cancer-related nausea. Despite this, it has become common clinical practice to prescribe ondansetron for nausea for non-cancer-related nausea.

In this series, we seek to understand the role of ondansetron for people with nausea unrelated to cancer treatment. The focus is on the patient profile when it is used, the drug's efficacy, and the associated adverse effects.

You can collect data for this series to help us better understand the effects of this medication.

GET INVOLVED

LEARN more - read the series manual (pdf, 389kb)

collect data - download the case report form (pdf, 248kb)

PERT for Pancreatic Cancer - series 53

A common complication of pancreatic cancer is pancreatic exocrine insufficiency (PEI), caused by the cancer directly, or functionally through blocked ducts. This lack of enzyme secretion into the duodenum often leads to malabsorption and symptoms such as bloating, wind, nausea, abdominal pain, diarrhoea and anorexia. 

The treatment for PEI is pancreatic enzyme replacement treatment (PERT), a biological medication administered in capsule form which aids in digestion. There is evidence that PERT is well tolerated and helps with symptom management, weight stabilisation, the ability to tolerate oncology treatments, and even survival. However, there is also published literature highlighting the low rates of prescribing PERT among clinicians for people with pancreatic cancer around the world. 

This study seeks to understand clinicians’ prescribing practices, and explore the use, efficacy and safety of PERT for patients with pancreatic cancer. 

get involved

learn more - read the series manual (pdf, 214kb)

collect data - download the case report form (pdf, 421kb)

Ranitidine or Famotidine for Malignant Bowel Obstruction - series 56

Are you prescribing H2 antagonists such as Ranitidine or Famotidine for malignant bowel obstruction? 

Older woman with blonde hair and cream sleeveless top sits on edge of bed clutching her tummy

Malignant bowel obstruction (MBO) is a common and serious complication of advanced cancer, with a poor prognosis. In cases of inoperable MBO, the primary objective is to alleviate distressing symptoms, such as nausea and vomiting

Ranitidine and famotidine are histamine (H2) receptor antagonists (H2 antagonists) that are sometimes used to reduce gastric secretion, thereby improving vomiting. To date, no study has been published looking at how effective and safe these medications are in MBO patients in a palliative care setting. The current evidence base in this area is insufficient to make any recommendations.

Your contribution to this study will help us examine the current clinical practice, and the benefits and harms of ranitidine or famotidine use in MBO and how effective it is in reducing vomiting.

get involved

learn more - read the series Manual (pdf, 222kb)

Collect data - download the case Report Form (pdf, 372kb)

Temazepam for insomnia - series 47

What is the real clinical experience when people in palliative care receive Temazepam for insomnia?

In this series, we will explore the use, efficacy and safety of Temazepam, a benzodiazepine, for the treatment of insomnia in palliative care.

Insomnia impacts physical, psychological and social aspects of life. Improving sleep using safe, effective and accessible pharmacotherapy is a tangible way to improve quality of life for people receiving palliative care.

But, there are challenges with prescribing benzodiazepines, especially when co-prescribed with opioids. You can collect data for this series to help us better understand the clinical experience of Temazepam for insomnia.

get involved

learn more - read the series manual (pdf, 134kb)

collect data - download the case report form (pdf, 342kb)

Nursing

Dressings for malignant cutaneous wounds - series 38

Can you help us? If you are looking after wounds that won't heal, we want to hear from you. You can collect data to help us understand common practices for managing malignant cutaneous wounds.

Hands in medical gloves preparing dressing tray including gauze and scissors

In this series, we want to identify the wound management procedures clinicians use for malignant cutaneous wounds, how clinicians decide on what course of management they will take for the wound, and which management/s achieve the goals of care.

Malodour is an overwhelming concern for the person with the wound, their family, and carers. The physiological, psychological and sociological consequences of living with a malodorous wound have a dramatic impact on comfort, pain, and quality of life.

The holistic management of these wounds is challenging. There is no robust evidence for which of the current treatment options are the most effective at improving quality of life or managing symptoms. Join this series to improve the evidence for best practice.

get involved

learn more - read the series Manual (pdf, 140kb)

Collect data - download the case Report Form (pdf, 605kb)

Nursing interventions for disorientation - series 29

Seeking nurses caring for people who are disoriented. We need your insights to help us understand if current orientation strategies are effective.

Confused senior lady looking at carer

Despite clinical guideline recommendations for orientation strategies for disoriented persons, there is a lack of evidence that such strategies are effective or even acceptable to them.

Disorientation is a common problem for people receiving care in hospitals and other facilities. Influencing factors include unfamiliarity of the environment, sensory impairment, prior cognitive impairment, and the impacts of physical illness and medical treatment on a person’s awareness and cognition.

Your data will contribute to our understanding of whether nurses’ use of orientation strategies for disorientated persons in their care are effective and acceptable.

get involved

Learn more - read the series manual (PDF, 431KB)

Collect data - download the case Report Form (PDF, 183KB)

Acknowledgement of Country

UTS acknowledges the Gadigal People of the Eora Nation and the Boorooberongal People of the Dharug Nation upon whose ancestral lands our campuses now stand. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands. 

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