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AIMI partners with Australian and international universities, state and federal government agencies, and a variety of industry and commercial partners to deliver cutting-edge fundamental and translational research outcomes.
Projects
AusGEM – EMAI at NSW DPI
The Australian Centre for Genomic Epidemiological Microbiology (AusGEM) was established in 2013 as a joint research program between AIMI and the NSW Department of Primary Industries through its Elizabeth Macarthur Agricultural Institute (EMAI).
In its initial two phases, AusGEM focused on antimicrobial resistance (AMR) and Mycoplasma vaccine development. Following the success of the these, AusGEM entered and is now approaching the end of its third phase, and has expanded its project scope to maximise EMAI research priorities and AIMI expertise. These projects encompass agriculture, biosecurity, food safety, animals and livestock, and genomics/bioinformatics.
AusGEM has now evolved into three focused networks: AusGEM AMR, AusGEM Vaccines, and AusGEM Diagnostics.
Metagenomics based diagnostics to control urinary tract infections – NSW Health
Spinal cord injury patients are at high risk of catheter-associated urinary tract infections (CAUTI), including infection by multi-drug resistant organisms. As well as impacting a patient’s quality of life and increasing their risk of life-threatening infection, CAUTIs increase hospital costs and can cause drug-resistant germs to spread.
Better monitoring patients to predict when they are at increased risk of CAUTI can enable physicians to intervene earlier and employ alternative strategies to prevent an infection, rather than relying solely on the use of antibiotics.
Work by AIMI faculty (A/Professor Diane McDougald, A/Prof Iain Duggin, and colleagues) shows that patients’ catheters are colonised by a diverse community of bacteria. Those communities change in species composition when there is a disturbance; for example, through inappropriate antibiotic therapy or colonisation with a pathogen that could lead to a CAUTI.
This discovery led to a New South Wales Health-funded project to develop a robust, simpler and cheaper methodology to monitor the microbial community for changes in composition, providing an early warning when a patient may be moving towards an infected status.
The project is also developing a mixed species biofilm system for laboratory evaluation of interventions aimed at controlling or eradicating biofilms on catheters. Our team will further use this laboratory system to investigate the mechanisms used by pathogenic bacteria to invade otherwise non-pathogenic microbial communities to cause infections. This will lead to new strategies for infection control and the development of novel diagnostic technologies to better treat and prevent infection within a high-risk patient population. The benefits would be improved quality of life, reduced mortalities, reduced spread of drug-resistant bacteria and significant cost savings to hospitals.
Cooperative Research Centre for Solving Antimicrobial resistance in Agribusiness, Food and Environments (CRC SAAFE)
AIMI is a partner in the recently announced CRC SAAFE led by Professor Erica Donner at The University of South Australia.