Dr Tuan V Nguyen is a Professor of Predictive Medicine at the School of Biomedical Engineering and Centre of Health and Technologies, and a Senior Principal Fellow of the Garvan Institute of Medical Research. He also holds appointments as Professor, St Vincent's Clinical School, UNSW Medicine, UNSW Australia, and Adjunct Professor of Epidemiology and Biostatistics, School of Medicine, University of Notre Dame, Australia. He holds two doctorates in medicine and science (D.Sc., PhD). The primary focus of his research is on the discovery and translation of genetic and aetiologic factors that determine an individual's risk of fracture. He pursues both genetic and epidemiological research, often combining the two, to address issues that are transformational, shaping policy and practice leading to better treatment and control of osteoporosis. He is one of the highly cited scientists in the field of osteoporosis and medicine. He is an elected Fellow of the American Society for Bone and Mineral Research, and elected Fellow of the Australian Academy of Health and Medical Sciences.
Dr. Nguyen has been pioneering in the development of predictive models for assessing fracture risk and better disease management. One of his achievements is the translation of 20-year research into a prognostic tool called “Garvan Fracture Risk Calculator” for assessing fracture risk for an individual. This model was developed based on the concept of individualised assessment which he had advanced previously. The model has been implemented in mobile devices and a dedicated website (www.fractureriskcalculator.com) which has been used by doctors and patients from all over the world. Dr Nguyen is a prominent figure in the field of genetics of osteoporosis through his work since mid-1990s. His group has demonstrated the contributions of polymorphisms in the VDR, COLIA1, LRP5, and FTO genes to the prediction of fracture risk. Recently, the group has participated in international consortia that have discovered 56 bone mass loci. The group is now engaging in whole genome sequencing to identify rare genetic variants for bone mass. His vision is to create a "genomic signature" and to incorporate this signature into his Fracture Risk Calculator for individualising the risk of fracture and comorbidities.
Dr Nguyen has published more than 300 peer-reviewed publications, review articles, book chapters, and commentaries or editorials, largely from his current research interests. His work has been published in highest impact journals in the field, notably the J Bone Miner Res, J Clin Endocrinol Metab. A number of key papers are published in more general journals, including New England Journal of Medicine, Lancet, JAMA, BMJ, Ann Int Med, Nature, Nature Genetics. Some papers are considered pioneering in the field and have received applauded commentaries. His papers have been cited moe than 30,000 times; of which, 50 papers have been cited more than 100 times. His careerwise H index is 87 (Scopus).
Dr Nguyen has extensive research collaboration, both nationally and internationally. He has been appointed Distinguished Visiting Professor of the School of Medicine, University of Danang (Vietnam); Distingusihed Visiting Professor ofTon Duc Thang University (Vietnam); Honorary Professor of Hanoi University of Pharmacy (Vietnam); Visiting Professor of Hanoi Medical School (Vietnam) and Khon Kaen University School of Medicine (Thailand). During the past 15 years, he has conducted many workshops in osteoporosis, evidence based medicine, research methodology, scientific writing, epidemiology & biostatistics in Thailand and Vietnam. His highly popular workshops have attracted and improved research capacity for thousands of doctors, health care professionals, and scientists. He has been credited for having contributed to raising the scientific publication profile of Vietnam in the international arena. He has published 12 books in Vietnam and has received a number of national awards and honours for his work in his native country. He has recently helped establish a bone and muscle research laboratory in Vietnam. This lab is conducting large scale clinical and research projects, including the Vietnam Osteoporosis Study (VOS), that complement his work in Australia.
Internationally and nationally, Dr Nguyen is well recognised as a leader in the epidemiology of osteoporosis. He has been elected as a Fellow of the American Society for Bone and Mineral Research. He was also awarded the prestigious Australian National Health and Medical Research Council (NHMRC) Senior Research Fellowship in 2008. Dr Nguyen has contributed to the profession through his services in journal editorial boards and peer review. He has served on the Publication Committee of the American Society for Bone and Mineral Research (2008-2012). Currently, he is an Associate Editor of the Journal of Bone and Mineral Research; Academic Editor of Scientific Reports, PLoS ONE, PeerJ, and BMC Musculoskel Disorders; and on the editorial board of Osteoporosis International, and Journal of Clinical Endocrinology and Metabolism, Journal of Endocrine Society, Osteoporosis and Sarcopenia. He is a regular reviewer for more than 20 medical and bone journals. He also contributed to grant review for many funding agencies around the world, including NHMRC, Wellcome Trust, NIH, WHO, Elan (Germany), New Zealand, Iceland, Israel, Hong Kong, Saudi Arabia.
Professor Nguyen has been regularly invited to lecture in major osteoporosis conferences in Asia and USA, including the annual scientific meetings of the American Society for Bone and Mineral Research, annual scientific meetings of the Australian & New Zealand Bone and Mineral Society, annual scientific meetings of the International Bone & Mineral Society, the World Federation of Nuclear Medicine and Biology, Sydney Australia. He has also been invited to serve on organising committees of various international meetings, including the 16th AFES (ASEAN Federation of Endocrine Societies) Congress, and Strong Bone Asia. He is chairing the 4th Pan Asia Conference in Biomedicine in 2018.
Genetics of complex diseases; genomewide association analysis; development of predictive models; risk factors for osteoporosis and osteoarthritis.
Osteoporosis; population genetics; design and analysis of clinical research; genomic analysis
Genetic Epidemiology of Osteoporosis Lab, Garvan Institute of Medical Research, Australia.
Bone and Muscle Research Lab, Ton Duc Thang University, Vietnam.