A/Prof Tapan Rai is Director, Researcher Development in the Graduate Research School. He has held academic and leadership positions in Australia, Canada, USA and India, and has been working in the researcher development space for ten years. In this capacity, he has advised over 200 HDR students and researchers on research methodology, and contributed to the development of university-wide and within-faculty researcher training programmes. Tapan joined UTS with the special portfolio of Statiatical Consulting in 2012 and was appointed Mathematical Science Discipline Leader in 2015, before taking up his current role in 2017.
Tapan works with researchers and research teams from a wide variety of disciplines including Health and Medical Sciences, Social Sciences, Education, Forensic Science, Engineering, Information Technology, Business and Law. He is an experienced biostatistician and is currently a chief investigator and lead biostatistician on three NHMRC-funded clinical trials:
- Enhancing Rehabilitation Services for Aboriginal Australians After Brain Injury. NHMRC Partnership Grant, APP1132468, $1,994,201, 2017-2021.
- COMPARE- Constraint Induced or Multi-Modal aphasia rehabilitation: An RCT of therapy for stroke related chronic aphasia. NHMRC Grant, APP 1083010, $998,167, 2015-2018.
- Very Early Rehabilitation in SpEech: An RCT of aphasia therapy after stroke. NHMRC Grant, APP1044973, $742,000, 2013-2017.
Tapan is a Fellow of the Royal Statistical Society and a member of the Statistical Society of Australia and of the International Biometric Society. He is a member of the Editorial Board of Statistical Associates Publishing.
Can supervise: YES
Tapan's broad research area is Statistics, with a specific interest in Biostatistics. As a statistician, he has worked in a wide variety of research areas. The current ones include:
- Design and Analysis of Clinical Trials
- Rehabilitation of post-stroke aphasia
- Rehabilitation Services for Aboriginal Australians After Brain Injury
- Measures of aphasia recovery
- Information Security and Privacy in Linked Databases
- Use of Mobile Devices in Teaching
Tapan leads the GRS Researcher Development, which consists of:
- General Reseacher Development (for Higher Degree by Research Students)
- ECR Connect
- Qualitative Research Methods
- Quantitative Research Methods
- Research Literacies
- Research Supervisor Development
As a statistician, his primary disciplinary teaching area is Quantitative Research Methods. However, he also teaches in the General Researcher Development Program, ECR Connect and the Research Supervisor Development Program.
Wang, S, Leslie, L, Rai, T, Speer, M & Kuleshov, Y 2020, 'Analysis of a Southerly Buster Event and Associated Solitary Waves', Journal of Southern Hemisphere Earth Systems Science.View/Download from: Publisher's site
This paper is a detailed case study of the southerly buster of October 6-7, 2015, along the New South Wales coast. It takes advantage of recently available Himawari-8 high temporal- and spatial-resolution satellite data, and other observational data. The data analyses support the widespread view that the southerly buster is a density current, coastally trapped by the Great Dividing Range. In addition, it appears that solitary waves develop in this event because the prefrontal boundary layer is shallow and stable. A simplified density current model produced speeds matching well with observational southerly buster data, at both Nowra and Sydney airports. Extending the density current theory, to include inertia-gravity effects, suggests that the solitary waves travel at speeds approximately 20% faster than the density current. This speed difference is consistent with the high-resolution satellite data, which shows the solitary waves moving increasingly ahead of the leading edge of the density current.
Rose, ML, Copland, D, Nickels, L, Togher, L, Meinzer, M, Rai, T, Cadilhac, DA, Kim, J, Foster, A, Carragher, M, Hurley, M & Godecke, E 2019, 'Constraint-induced or multi-modal personalized aphasia rehabilitation (COMPARE): A randomized controlled trial for stroke-related chronic aphasia.', International Journal of Stroke, vol. 14, no. 9, pp. 972-976.View/Download from: Publisher's site
RATIONALE:The comparative efficacy and cost-effectiveness of constraint-induced and multi-modality aphasia therapy in chronic stroke are unknown. AIMS AND HYPOTHESES:In the COMPARE trial, we aim to determine whether Multi-Modal Aphasia Treatment (M-MAT) and Constraint-Induced Aphasia Therapy Plus (CIAT-Plus) are superior to usual care (UC) for chronic post-stroke aphasia. Primary hypothesis: CIAT-Plus and M-MAT will reduce aphasia severity (Western Aphasia Battery-Revised Aphasia Quotient (WAB-R-AQ)) compared with UC: CIAT-Plus superior for moderate aphasia; M-MAT superior for mild and severe aphasia. SAMPLE SIZE ESTIMATES:A total of 216 participants (72 per arm) will provide 90% power to detect a 5-point difference on the WAB-R-AQ between CIAT-Plus or M-MAT and UC at α = 0.05. METHODS AND DESIGN:Prospective, randomized, parallel group, open-label, assessor blinded trial. Participants: Stroke >6 months; aphasia severity categorized using WAB-R-AQ. Computer-generated blocked and stratified randomization by aphasia severity (mild, moderate, and severe), to 3 arms: CIAT-Plus, M-MAT (both 30 h therapy over two weeks); UC (self-reported usual community care). STUDY OUTCOMES:WAB-R-AQ immediately post-intervention. Secondary outcomes: WAB-R-AQ at 12-week follow-up; naming scores, discourse measures, Communicative Effectiveness Index, Scenario Test, and Stroke and Aphasia Quality of Life Scale-39 g immediately and at 12 weeks post-intervention; incremental cost-effectiveness ratios compared with UC at 12 weeks. DISCUSSION:This trial will determine whether CIAT-Plus and M-MAT are superior and more cost-effective than UC in chronic aphasia. Participant subgroups with the greatest response to CIAT-Plus and M-MAT will be described.
Buis, R, Rust, L, Nizio, KD, Rai, T, Stuart, BH & Forbes, SL 2019, 'Investigating the Sensitivity of Cadaver- Detection Dogs to Aged, Diluted Decomposition Fluid', Journal of Forensic Identification, vol. 69, no. 3, pp. 367-377.
Cadaver-detection dogs (also known as human remains detection dogs) are used worldwide to locate deceased victims and human remains. Ethical restrictions often prevent the dog handlers from using cadavers as training aids, resulting in a reliance on pseudo-scents or human tissues, such as blood, bone, and decomposition fluid. Often these aids must be re-used many times because of the difficulty in obtaining new materials. The aim of this study was to investigate the dogs' sensitivity to aged human decomposition fluid samples that are used as a training aid. Human decomposition fluid was collected and serially diluted to 1 part-per-trillion (10u) and aged up to two years. The samples were presented throughout the aging process to three police accredited cadaver-detectior. dog teams under standard indoor training conditions. The dogs were capable of detecting the oldest and lowest dilution levels of decomposition fluid samples. Ongoing training to retain this level of sensitivity is recommended. The results of these trials indicate human decomposition fluid is a valid training aid for cadaver-detection dogs.
Lees, T, Elliott, JL, Gunning, S, Newton, PJ, Rai, T & Lal, S 2019, 'A systematic review of the current evidence regarding interventions for anxiety, PTSD, sleepiness and fatigue in the law enforcement workplace', INDUSTRIAL HEALTH, vol. 57, no. 6, pp. 655-667.View/Download from: Publisher's site
Godecke, E, Rai, T, Cadilhac, DA, Armstrong, E, Middleton, S, Ciccone, N, Whitworth, A, Rose, ML, Holland, A, Ellery, F, Hankey, GJ & Bernhardt, J 2018, 'Statistical analysis plan (SAP) for the Very Early Rehabilitation in Speech (VERSE) after stroke trial: an international 3-arm clinical trial to determine the effectiveness of early, intensive, prescribed, direct aphasia therapy', INTERNATIONAL JOURNAL OF STROKE, vol. 13, no. 8, pp. 863-880.View/Download from: Publisher's site
Prior, J & Rai, T 2017, 'Engaging with residents' perceived risks and benefits about technologies as a way of resolving remediation dilemmas.', Science of the Total Environment, vol. 601-602, pp. 1649-1669.View/Download from: Publisher's site
In recent decades the diversity of remediation technologies has increased significantly, with the breadth of technologies ranging from dig and dump to emergent technologies like phytoremediation and nanoremediation. The benefits of these technologies to the environment and human health are believed to be substantial. However, they also potentially constitute risks. Whilst there is a growing body of knowledge about the risks and benefits of these technologies from the perspective of experts, little is known about how residents perceive the risks and benefits of the application of these technologies to address contaminants in their local environment. This absence of knowledge poses a challenge to remediation practitioners and policy makers who are increasingly seeking to engage these affected local residents in choosing technology applications. Building on broader research into the perceived benefits and risks of technologies, and data from a telephone survey of 2009 residents living near 13 contaminated sites in Australia, regression analysis of closed-ended survey questions and coding of open-ended questions are combined to identify the main predictors of resident's perceived levels of risk and benefit to resident's health and to their local environment from remediation technologies. This research identifies a range of factors associated with the residents' physical context, their engagement with institutions during remediation processes, and the technologies which are associated with residents' level of perceived risk and benefit for human health and the local environment. The analysis found that bioremediation technologies were perceived as less risky and more beneficial than chemical, thermal and physical technologies. The paper also supports broader technology research that reports an inverse correlation between levels of perceived risks and benefits. In addition, the paper reveals the types of risks and benefits to human health and the local environment that...
Prior, J, Hubbard, P & Rai, T 2017, 'Using residents' worries about technology as a way of resolving environmental remediation dilemmas', Science of the Total Environment, vol. 580, pp. 882-899.View/Download from: Publisher's site
The choice of technologies used to remediate contaminated environments are increasingly made via engagement with affected local residents. Despite this, little is known about how residents perceive remediation technology applications. Building on the findings of broader technology worry research, and drawing on data from a telephone survey of 2009 residents living near thirteen contaminated sites in Australia, regression analysis of closed-ended survey questions and coding analysis of open-ended survey questions are combined to identify the main predictors of worries concerning particular remediation technologies, and how worry affects them. This suggests respondents are more worried about the application of chemical remediation technologies than the application of physical and thermal technologies, which in turn caused more worry than the application of biotechnology. The paper suggests that these worries can be reduced via direct engagement with residents about remediation technologies, suggesting that such engagement can provide knowledge that improves remediation technology decisions.
Ciccone, N, West, D, Cream, A, Cartwright, J, Rai, T, Granger, A, Hankey, GJ & Godecke, E 2016, 'Constraint-induced aphasia therapy (CIAT): a randomised controlled trial in very early stroke rehabilitation', APHASIOLOGY, vol. 30, no. 5, pp. 566-584.View/Download from: Publisher's site
Godecke, E, Armstrong, E, Rai, T, Middleton, S, Ciccone, N, Whitworth, A, Rose, M, Holland, A, Ellery, F, Hankey, G, Cadilhac, D & Bernhardt, J 2016, 'A randomized controlled trial of very early rehabilitation in speech after stroke', International Journal of Stroke, vol. 11, no. 5, pp. 586-592.View/Download from: Publisher's site
Rationale: The efficacy of rehabilitation therapy for aphasia caused by stroke is uncertain.
Aims and hypothesis: The Very Early Rehabilitation of Speech (VERSE) trial aims to determine if intensive prescribed aphasia therapy (VERSE) is more effective and cost saving than non-prescribed, intensive (usual care-plus) and non-intensive usual care (UC) therapy when started within 15 days of stroke onset and continued daily over four weeks. We hypothesize that aphasia therapy when started very early after stroke and delivered daily could enhance recovery of communication compared with UC.
Sample size estimates: A total of 246 participants (82 per arm) will provide 80% power to detect a 4.4% improvement on aphasia quotient between VERSE and UC plus at a significance level of α = 0.05.
Setting: Acute-care hospitals and accompanying rehabilitation services throughout Australia, 2014–2017.
Design: Three-arm, prospective, randomized, parallel group, open-label, blinded endpoint assessment (PROBE) trial.
Participants: Acute stroke in previous 14 days and aphasia diagnosed by aphasia quotient (AQ) of the Western Aphasia Battery (WAB).
Randomization: Computer-generated blocked randomization procedure stratified by aphasia severity according to Western Aphasia Battery, to one of three arms.
Intervention: All participants receive UC—usual ward-based aphasia therapy. Arm 1: UC—no additional therapy; Arm 2: UC-plus usual ward-based therapy; Arm 3: VERSE therapy—a prescribed and structured aphasia therapy program. Arms 2 and 3 receive a total of 20 additional sessions (45–60 min, provided daily) of aphasia therapy. The additional intervention must be provided before day 50 post stroke.
Study outcome measures: The aphasia quotient of Western Aphasia Battery at 12 weeks post stroke. Secondary outcomes include discourse measures, the Stroke and Aphasia Quality of Life Scale-39 and the Aphasia Depression Rating Scale at 12 and 26 weeks.
Economic evaluation: Incremental cost-effectiven...
Godecke, E, Armstrong, E, Ciccone, N, Middleton, S, Rai, T, Cadilhac, D, Rose, M, Whitworth, A, Holland, A, Hankey, G, Ellery, F & Bernhardt, J 2015, 'Establishing large scale therapy ﬁdelity processes inthe Very Early Rehabilitation in SpEech (VERSE) clinical trial: Lessons learned', International Journal of Stroke, vol. 10, no. S3, pp. 13-13.
This study investigated how teachers are using distinctive pedagogical features of mobile learning: collaboration, personalisation and authenticity. The researchers developed and validated a survey instrument based on these three established constructs (Kearney, Schuck, Burden, & Aubusson, 2012) and used it to interrogate current mobile learning practices in school and university education. This paper focuses on data from school teachers (n = 107). Findings indicated that teachers' perceptions of authenticity were high but aspects of online collaboration, networking and student agency were rated surprisingly lower than expected, given the rhetoric about enhanced connection and flexible learning opportunities afforded by mobile technologies. Device ownership was identified as one factor influencing adoption of these mobile pedagogies. Implications for effective use of handheld devices in teaching are addressed.
Perrault, KA, Stefanuto, P-H, Stuart, BH, Rai, T, Focant, J-F & Forbes, SL 2015, 'Reducing variation in decomposition odour profiling using comprehensive two-dimensional gas chromatography', Journal of Separation Science, vol. 38, no. 1, pp. NA-NA.View/Download from: Publisher's site
Rai, T, Godecke, E, Armstrong, E, Ciccone, N, Middleton, S, Holland, A, Cadilhac, D, Whitworth, A, Rose, M, Hankey, G, Ellery, F & Bernhardt, J 2015, 'Very Early Rehabilitation in SpEech (VERSE) after stroke: On-going trial status', International Journal of Stroke, vol. 10, no. S3, pp. 13-13.View/Download from: Publisher's site
Rose, M, Copland, D, Nickels, L, Meinzer, M, Rai, T & Godecke, E 2015, 'COMPARE: A national randomized controlled trialcomparing two intensive treatments to usual care forindividuals with chronic aphasia', International Journal of Stroke, vol. 10, no. S3, pp. 77-77.View/Download from: Publisher's site
Wilkinson, AM, Johnson, CE, Walker, H, Colgan, V, Arnet, H & Rai, T 2015, 'Evaluating the Liverpool Care Pathway for care of the terminally ill in rural Australia', SUPPORTIVE CARE IN CANCER, vol. 23, no. 11, pp. 3173-3181.View/Download from: Publisher's site
Buis, R, Rust, L, Nizio, K, Rai, T, Stuart, B & Forbes, S 2015, 'Investigating the Sensitivity of Cadaver-Detection Dogs to Decomposition Fluid', Journal of Forensic Identification, vol. 65, no. 6, pp. 985-997.
Cadaver-detection dogs are regularly used by police and emergency services to locate human remains. Because of ethical restrictions, the dogs are not trained using cadavers, but instead, on pseudo-scents or human tissues, such as blood, bone, and decomposition fluid. However, the accuracy of these training aids as substitutes for human remains is unknown. The aim of this study was to investigate the dogs’ sensitivity to human decomposition fluid as a training aid and to determine whether their sensitivity increased with exposure.
Perrault, KA, Rai, T, Stuart, BH & Forbes, SL 2015, 'Seasonal comparison of carrion volatiles in decomposition soil using comprehensive two-dimensional gas chromatography - time of flight mass spectrometry', ANALYTICAL METHODS, vol. 7, no. 2, pp. 690-698.View/Download from: Publisher's site
Perrault, KA, Stefanuto, P-H, Stuart, BH, Rai, T, Focant, J-F & Forbes, SL 2015, 'Detection of decomposition volatile organic compounds in soil following removal of remains from a surface deposition site', FORENSIC SCIENCE MEDICINE AND PATHOLOGY, vol. 11, no. 3, pp. 376-387.View/Download from: Publisher's site
Perrault, KA, Stefanuto, P-H, Stuart, BH, Rai, T, Focant, J-F & Forbes, SL 2015, 'Reducing variation in decomposition odour profiling using comprehensive two-dimensional gas chromatography.', Journal of Separation Science, vol. 38, no. 1, pp. 73-80.View/Download from: Publisher's site
Challenges in decomposition odour profiling have led to variation in the documented odour profile by different research groups worldwide. Background subtraction and use of controls are important considerations given the variation introduced by decomposition studies conducted in different geographical environments. The collection of volatile organic compounds (VOCs) from soil beneath decomposing remains is challenging due to the high levels of inherent soil VOCs, further confounded by the use of highly sensitive instrumentation. This study presents a method that provides suitable chromatographic resolution for profiling decomposition odour in soil by comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry using appropriate controls and field blanks. Logarithmic transformation and t-testing of compounds permitted the generation of a compound list of decomposition VOCs in soil. Principal component analysis demonstrated the improved discrimination between experimental and control soil, verifying the value of the data handling method. Data handling procedures have not been well documented in this field and standardisation would thereby reduce misidentification of VOCs present in the surrounding environment as decomposition byproducts. Uniformity of data handling and instrumental procedures will reduce analytical variation, increasing confidence in the future when investigating the effect of taphonomic variables on the decomposition VOC profile.
Stefanuto, P-H, Perrault, KA, Lloyd, RM, Stuart, B, Rai, T, Forbes, SL & Focant, J-F 2015, 'Exploring new dimensions in cadaveric decomposition odour analysis', Anal. Methods.View/Download from: Publisher's site
Godecke, E, Armstrong, E, Middleton, S, Rai, T, Holland, AE, Cadilhac, D, Whitworth, A, Rose, M, Ciccone, N, Hankey, G & Bernhardt, J 2014, 'Very Early Rehabilitation in SpEech (VERSE): Progress report', INTERNATIONAL JOURNAL OF STROKE, vol. 9, pp. 48-48.
Godecke, E, Ciccone, NA, Granger, AS, Rai, T, West, D, Cream, A, Cartwright, J & Hankey, G 2014, 'A comparison of aphasia therapy outcomes before and after a Very Early Rehabilitation programme following stroke', International journal of language and communication disorders, vol. 49, no. 2, pp. 149-161.View/Download from: Publisher's site
Very early aphasia rehabilitation studies have shown mixed results. Differences in therapy intensity and therapy type contribute significantly to the equivocal results. This work compares a standardised, prescribed very early aphasia therapy regimen to a historical usual care control group at therapy completion (4-5 weeks post-stroke) and again at follow-up (six months).
Rai, T & Hall, JL 2014, 'Split Leverage: Attacking the Condentiality of Linked Databases by Partitioning', ANZIAM.
This paper considers the risk of disclosure in linked databases when statistical analysis of micro-data is permitted. The risk of dis- closure needs to be balanced against the utility of the linked data. The current work specifically considers the disclosure risks in permit- ting regression analysis to be performed on linked data. A new attack based on partitioning of the database is presented.
Elliott, R, Rai, T & McKinley, SM 2014, 'Factors affecting sleep in the critically ill: An observational study', Journal of Critical Care, vol. 29, no. 5, pp. 859-863.View/Download from: Publisher's site
Purpose The aims of the current study were to describe the extrinsic and intrinsic factors affecting sleep in critically ill patients and to examine potential relationships with sleep quality. Materials and Methods Sleep was recorded using polysomnography (PSG) and self-reports collected in adult patients in intensive care. Sound and illuminance levels were recorded during sleep recording. Objective sleep quality was quantified using total sleep time divided by the number of sleep periods (PSG sleep period time ratio). A regression model was specified using the PSG sleep period time ratio as a dependent variable. Results Sleep was highly fragmented. Patients rated noise and light as the most sleep disruptive. Continuous equivalent sound levels were 56 dB (A). Median daytime illuminance level was 74 lux, and nighttime levels were 1 lux. The regression model explained 25% of the variance in sleep quality (P = .027); the presence of an artificial airway was the only statistically significant predictor in the model (P = .007). Conclusions The presence of an artificial airway during sleep monitoring was the only significant predictor in the regression model and may suggest that although potentially uncomfortable, an artificial airway may actually promote sleep. This requires further investigation.
Godecke, E, Armstrong, E, Bernhardt, J, Middleton, S, Rai, T, Holland, A, Cadilhac, DA, Whitworth, A, Rose, M, Ciccone, N & Hankey, GJ 2013, 'Very Early Rehabilitation in SpEech (VERSE): the development of an Australian randomised controlled trial of aphasia therapy after stroke', INTERNATIONAL JOURNAL OF STROKE, vol. 8, pp. 44-45.
Godecke, E, Rai, T, Ciccone, NA, Armstrong, E, Granger, A & Hankey, G 2013, 'Amount of Therapy Matters in Very Early Aphasia Rehabilitation after Stroke: A Clinical Prognostic Model', Seminars in Speech and Language, vol. 34, no. 3, pp. 129-141.View/Download from: Publisher's site
Background and Aim: The effects of very early aphasia therapy on recovery are equivocal. This article examines predictors of very early aphasia recovery through statistical modeling. Methods: This study involved a secondary analysis of merged data from two randomized, single-blind trials conducted in Australian acute and subacute hospitals. Study 1 (n = 59) compared daily therapy to usual ward care for up to 4 weeks poststroke in patients with moderate to severe aphasia. Study 2 (n = 20) compared daily group therapy to daily individual therapy for 20 1-hour sessions over 5 weeks, in patients with mild to severe aphasia. The primary outcome measure was the Western Aphasia Battery Aphasia Quotient (AQ) at therapy completion. This analysis used regression modeling to examine the effects of age, baseline AQ and baseline modified Rankin Scale (mRS), average therapy amount, therapy intensity, and number of therapy sessions on aphasia recovery. Results: Baseline AQ (p = 0.047), average therapy amount (p = 0.030), and baseline mRS (p = 0.043) were significant predictors in the final regression model, which explained 30% (p < 0.001) of variance in aphasia recovery. Conclusion: The amount of very early aphasia therapy could significantly affect communication outcomes at 4 to 5 weeks poststroke. Further studies should include amount of therapy provided to enhance reliability of prognostic modeling in aphasia recovery.
Pugh, JD, Twigg, DE, Martin, T & Rai, T 2013, 'Western Australia facing critical losses in its midwifery workforce: A survey of midwives' intentions', Midwifery, vol. 29, no. 5, pp. 497-505.View/Download from: Publisher's site
Objective the ongoing attrition of the midwifery workforce frustrates future workforce planning and the provision of maternity services in Western Australia. This project determined factors contributing to the intention of the midwives to move jobs and/or leave the profession. Design a cross-sectional survey approach was taken for this descriptive research utilising a self-administered questionnaire developed by the Nursing and Midwifery Office, Department of Health, Western Australia. Setting public and private health sectors in Western Australia, AprilMay 2010. Participants 1,600 midwives employed in the public and private health sectors throughout Western Australia were invited to participate: 712 responded (44.5%), one-fifth of the state's registered midwives. Findings most midwives worked part-time in a clinical role in public hospitals. Almost half intended moving jobs within 5 years and/or leaving midwifery. Excluding midwives of retirement age, the most common reasons for intending to move jobs were family commitments, working conditions and role dissatisfaction. Those intending to leave midwifery cited work-life balance, career change and family commitments. Midwives thought addressing the following issues would improve midwifery retention: flexible work arrangements, remuneration, staffing and caseload, workplace culture, professional development and models of care.
Reid, AL, Millward, MJ, Lee, M, Frank, MH, Ireland, A, Monshizadeh, L, Rai, T, Heenan, P, Medic, S, Kumarasinghe, P & Ziman, M 2013, 'Markers of circulating tumour cells in the peripheral blood of patients with melanoma correlate with disease recurrence and progression', British Journal of Dermatology, vol. 168, no. 1, pp. 85-92.View/Download from: Publisher's site
Background:â Multimarker quantitative real-time polymerase chain reaction (qRT-PCR) represents an effective method for detecting circulating tumour cells in the peripheral blood of patients with melanoma. Objectives:â To investigate whether the phenotype of circulating melanoma cells represents a useful indicator of disease stage, recurrence and treatment efficacy. Methods:â Peripheral blood was collected from 230 patients with melanoma and 152 healthy controls over a period of 3 years and 9 months. Clinical data and blood samples were collected from patients with primary melanoma (early stages, 0âII, n = 154) and metastatic melanoma (late stages, IIIâIV, n = 76). Each specimen was examined by qRT-PCR analysis for the expression of five markers: MLANA, ABCB5, TGFÎ²2, PAX3d and MCAM. Results:â In total, 212 of the patients with melanoma (92%) expressed markers in their peripheral blood. Two markers, MLANA and ABCB5, had the greatest prognostic value, and were identified as statistically significant among patients who experienced disease recurrence within our study period, being expressed in 45% (MLANA) and 49% (ABCB5) of patients with recurrence (P = 0Â·001 and P = 0Â·031, respectively). For patients administered nonsurgical treatments, MCAM expression correlated with poor treatment outcome. Conclusions:â Circulating tumour cells were detectable at all stages of disease and long after surgical treatment, even when patients were considered disease free. Specifically, expression of ABCB5 and MLANA had significant prognostic value in inferring disease recurrence, while MCAM expression was associated with poor patient outcome after treatment, confirming multimarker qRT-PCR as a potential technique for monitoring disease status.
Godecke, E, Hird, K, Lalor, E, Rai, T & Phillips, M 2012, 'Very early poststroke aphasia therapy: a pilot randomized controlled efficacy trial', International Journal of Stroke, vol. 7, no. 8, pp. 635-644.View/Download from: Publisher's site
Background and purpose Early stroke rehabilitation has shown benefits over spontaneous recovery. Insufficient evidence exists to determine the benefits of early aphasia intervention. We hypothesized that daily aphasia therapy would show better communication outcomes than usual care (UC) in early poststroke recovery. Method This prospective, randomized, single-blinded, controlled trial was conducted in three acute-care hospitals in Perth, Australia, each with over 200 stroke admissions annually. Patients with acute stroke causing moderate to severe aphasia were recruited at a median of three-days (range: 0-10 days) to receive daily aphasia therapy or usual care therapy. Individually tailored, impairment-based intervention was provided for the acute hospital stay or intervention phase (median: 19 days; range: 5-76). Primary outcome measures were the aphasia quotient and functional communication profile at acute hospital discharge or four-weeks poststroke, whichever came first. A random-number generator and sealed envelopes were used to randomize participants. Assessments were completed by a blinded assessor. Results Fifty-nine participants were recruited, with six withdrawals (10%) and seven deaths (12%) at six-months. Ninety percent had ischemic strokes, with 56.5% experiencing a total anterior circulation stroke. The group mean (Â±SD) age was 69.1 (Â±13.9) years. Six participants (18.75%) in the daily aphasia therapy group did not complete the minimum (150 min) therapy required for this study. The daily aphasia therapy intervention phase mean therapy session time was 45 min (range: 30-80) and the total mean amount of therapy for the daily aphasia therapy participants was 331 min (range: 30-1415). Four (15%) participants in the usual care group received therapy. The collective total therapy provided to these participants was 295 min over seven sessions. Usual care participants received an average of 10.5 min of therapy per week during the intervention phase. At th...
Godecke, E, Armstrong, E, Rai, T, Cadilhac, D, Middleton, S, Ciccone, N, Rose, M, Whitworth, A, Ellery, F, Holland, A, Hankey, G & Bernhadt, J 2018, 'The Very Early Rehabilitation in Speech (VERSE) after stroke trial: an international 3-arm clinical trial to determine the effectiveness of early, intensive, prescribed, direct aphasia therapy', Frontiers in Human Neuroscience, Academy of Aphasia Concference, Frontiers Media, Montreal, Canada.View/Download from: Publisher's site
Rai, T, Godecke, E, Armstrong, E, Cadilhac, D, Ciccone, N, Rose, M, Holland, A, Whitworth, A, Ellery, F, Hankey, G, Middleton, S & Bernhardt, J 2019, 'Fewer but Longer Treatment Sessions for Aphasia Are Associated with Better Recovery in The Very Early Rehabilitation in Speech (Verse) Clinical Trial Cohort', European Stroke Journal, European Stroke Organisation Conference, SAGE Publications, Milan, pp. 32-32.
Angelini, M, Prescott, A, Schuck, S, Rai, T, Lee, C & Coupland, M 2017, '“Maths Inside”: A Project to Raise Interest in Mathematics', 40 years on: We are still learning! Proceedings of the 40th Annual Conference of the Mathematics Education Research Group of Australasia, Mathematics Education Research Group of Australasia, 40th Annual Conference, MERGA : Mathematics Education Research Group of Australasia, Melbourne, pp. 181-188.
In this paper, we provide an overview of the “Maths Inside” project, funded by the Australian Maths and Science Partnership Program (AMSPP). The overall aim of the AMSPP is to improve uptake and participation of students in mathematics and science at secondary and tertiary levels. In this research project, we aim to improve student interest in mathematics and support mathematics teachers in their professional learning, through
provision of rich and investigative learning resources, including video case studies of CSIRO scientists and mathematicians. Data collection on the outcomes of the project is ongoing and will be reported in subsequent papers
Godecke, E, Armstrong, E, Rai, T, Middleton, S, Ciccone, N, Rose, M, Holland, A, Whitworth, A, Ellery, F, Hankey, G, Cadilhac, D & Bernhardt, J 2018, 'Very Early Rehabilitation in Speech (VERSE) A Prospective, Randomised, Controlled, Trial, Open-Label, Blinded-Endpoint Trial in Patients With Aphasia Following Acute Stroke', International Journal of Stroke, World Stroke Congress, SAGE Publications, Montreal, Canada, pp. 234-234.
Rai, T, Uggen, T & Godecke, E 2018, 'Automated Classification of Post-Stroke Aphasia by Severity', Conference of the International Clinical Biostatistics, Melbourne, Australia.
Uggen, T, Rai, T & Godecke, E 2018, 'Automated Classification of Post-Stroke Aphasia by Severity', International Biometrics Society Conference, Barcelona, Spain.
Godecke, E, Armstrong, E, Middleton, S, Ciccone, N, Rai, T, Holland, A, Whitworth, A, Rose, M, Ellery, F, Cadilhac, D, Hankey, G & Bernhardt, J 2017, 'Therapy fidelity and trial progress in the Very Early Rehabilitation in SpEech (VERSE) trial', International Journal of Stroke, Annual Scientific Meeting of the Stroke Society of Australasia, Sage Journals, Queenstown, New Zealand.
Pierce, JE, Foster, A, Hurley, M, O’Halloran, R, Rose, M, Nickels, L, Togher, L, Meinzer, M, Copland, D, Rai, T, Godecke, E, Joosup, K & Cadilhac, D 2017, 'Treatment for people with chronic aphasia – Investigation of high and low intensity, constraint and multimodal treatments', International Journal of Stroke, Smart Strokes, Gold Coast, QLD.
Buis, R, Rust, L, Nizio, K, Perrault, K, Rai, T, Stuart, B & Forbes, S 2017, 'IS HUMAN DECOMPOSITION FLUID A VALID TRAINING AID FOR CADAVER-DETECTION DOGS?', FORENSIC SCIENCE INTERNATIONAL, 21st Triennial Meeting of the International-Association-of-Forensic-Sciences (IAFS), ELSEVIER IRELAND LTD, Toronto, CANADA, pp. 252-252.
Godecke, E, Armstrong, E, Ciccone, N, Middleton, S, Rai, T, Holland, A, Ellery, F, Cadilhac, D, Whitworth, A, Rose, M, Hankey, G & Bernhardt, J 2016, 'Very Early Rehabilitation in SpEech (VERSE) after stroke: trial status and recruitment', European Stroke Organisation Conference, Barcelona, Spain.
Godecke, E, Armstrong, E, Ciccone, N, Middleton, S, Rai, T, Holland, A, Whitworth, A, Rose, M, Cadilhac, D, Hankey, G & Bernhardt, J 2015, 'A protocol outlining treatment fidelity processes in the Very Early Rehabilitation in SpEech (VERSE) clinical trial', Clinical Aphasiology Conference, Monterey, CA, USA.
Godecke, E, Armstrong, E, Ciccone, N, Middleton, S, Rai, T, Holland, A, Whitworth, A, Rose, M, Ellery, F, Cadilhac, D, Hankey, G & Bernhardt, J 2016, 'The progress of a complex rehabilitation randomised controlled trial: Very Early Rehabilitation in SpEech (VERSE) after stroke', Speech Pathology Australia National Conference, Perth, Australia.
Godecke, E, Armstrong, E, Ciccone, N, Middleton, S, Rai, T, Holland, A, Whitworth, A, Rose, M, Ellery, F, Cadilhac, D, Hankey, G & Bernhardt, J 2016, 'Therapy fidelity in the Very Early Rehabilitation in SpEech (VERSE) aphasia after stroke randomised controlled trial (RCT): Lessons learned and progress to date', Speech Pathology Australia National Conference, Perth, Australia.
Godecke, E, Armstrong, E, Middleton, S, Rai, T, Ciccone, N, Holland, A, Whitworth, A, Rose, M, Ellery, F, Cadilhac, D, Hankey, G & Bernhardt, J 2016, 'Trial status and recruitment: Very Early Rehabilitation in SpEech (VERSE) after stroke trial', Asia Pacific Stroke Conference, Brisbane, Australia.
Rose, M, Copland, D, Nickels, L, Togher, L, Meinzer, M, Rai, T, Godecke, E, Kim, J, Cadilhac, D, Pierce, J, Foster, A & Hurley, M 2016, 'Progress On Compare: A Randomised Controlled Trial Comparing Constraint-Induced And Multi-Modal Aphasia Therapy To Usual Care In People With Chronic Aphasia', Smart Strokes, Canberra, Australia.
Rose, M, Copland, D, Nickels, L, Togher, L, Meinzer, M, Rai, T, Godecke, E, Pierce, J, Foster, A & Hurley, M 2016, 'COMPARE: A randomised controlled trial comparing constraint-induced and multi-modal aphasia therapy to usual care in people with chronic aphasia', World Conference in Neurorehabilitation, Philadelphia, PA, USA.
Uggen, T, Rai, T & Godecke, E 2016, 'Selecting outcome measures and statistical models in neurological clinical trials that measure functional outcomes', International Biometric Society Conference, Victoria, BC, Canada.
Godecke, E, Armstrong, E, Bernhardt, J, Middleton, S, Rai, T, Holland, A, Cadilhac, D, Whitworth, A, Rose, M, Ciccone, N & Hankey, G 2015, 'Assessment of therapy fidelity processes in the very early rehabilitation in speech (verse) clinical trial', International Journal of Stroke, European Stroke Organization Conference, Wiley: 12 months, Glasgow, Scotland, UK, pp. 424-424.
Uggen, T, Rai, T & Godecke, E 2015, 'Statistical modelling of post-stroke aphasia recovery', Inter-university Neuroscience & Mental Health Conference, Sydney, NSW, Australia.
Ciccone, N, Godecke, E, Cream, A, West, D, Cartwright, J, Granger, A, Rai, T & Hankey, G 2014, 'Group or individual therapy in very early aphasia recovery: Does therapy type matter?', International Aphasia Rehabilitation Conference, The Hague, The Netherlands.
Godecke, E, Armstrong, E, Bernhardt, J, Middleton, S, Rai, T, Holland, A, Cadilhac, D, Whitworth, A, Rose, M, Ciccone, N & Hankey, G 2014, 'Progress on an Australian randomised controlled trial of aphasia therapy after stroke', International Aphasia Rehabilitation Conference, The Hague, The Netherlands.
Godecke, E, Armstrong, E, Bernhardt, J, Middleton, S, Rai, T, Holland, A, Cadilhac, D, Hankey, G, Whitworth, A, Rose, M & Ciccone, N 2013, 'An RCT of aphasia therapy after stroke', British Aphasiology Symposium, Manchester, UK.
Godecke, E, Rai, T, Ciccone, NA, Granger, AS, West, D, Cream, A, Cartwright, J & Hankey, G 2012, 'Does the amount of aphasia therapy in the first 4-5 weeks after stroke improve outcome? Very Early Rehabilitation in SpEech-II (VERSE II)', Cerebrovascular Diseases, European Stroke Conference, Karger, Lisbon, Portugal, pp. 42-42.View/Download from: Publisher's site
Dare, J, Wilkinson, C & Rai, T 2011, 'The forgotten Australians: an investigation of alcohol use amongst senior citizens', Australasian Professional Society on Alcohol and other Drugs (APSAD) Conference, Hobart, Tasmania.
Rai, T 2014, A review of back pain related Work Cover NSW cases by nominal insurers 2008-2011, no. 201300174, pp. 1-44, Sydney.
Rai, T 2014, Report on Project Protocols, no. 2014002036, pp. 1-88, Sydney.
Pettitt, A, Rai, T, Alexander, S, Carstens, J, Gamachchi, A, Hall, J & Stebila, D 2013, Disclosure-Protected Regression Coefficients with Linked Micro-Data, pp. 1-3, Brisbane.
Rai, T 2013, Data Analysis of Cobalt and Chromium Ion Levels in Arthroplasty Patients, no. 2013001271, pp. 1-38, Sydney.
Rai, T 2013, Factors influencing the success of vaginal birth after a caesarean section, no. 2013001375, pp. 1-21, Sydney.
Rai, T 2013, Report on the 2013 Library Materials Availability Survey, pp. 1-8, Sydney.
Rai, T 2013, The Statistical Methodology Used to Assess the Effect of Limestone Addition to General Purpose Cement, no. 2013001253, pp. 1-17, Sydney.
Rai, T, Pettitt, A & Hall, J 2013, Disclosure Risks Associated With Statistical Modelling of Linked Data, pp. 1-18, Brisbane.
Tapan's research is developed in partnership with a number of industry partners. Some of the partners on his current projects include:
- National Stroke Foundation
- WA Department of Health
- Neurological Council of WA
- WA Country Health Service
- Royal Perth Hospital Medical Research Foundation
- Sir Charles Gairdner Hospital
- Fiona Stanley Hospital
- St John of God Hospital
- Kimberley Aboriginal Medical Services Council
- Bega Garnbirringu Health Service
- Geraldton Regional Aboriginal Medical Service
- Bureau of Meterology