Dr Sj Sijie Shen is a researcher in respiratory and gastrointestinal tract diseases, with a major focus on the interaction between host immunity and microbiomes. He has a special interest in the role diet plays in immune responses and disease progression.
Dr Shen completed his Bachelor of Biomedical Sciences (Honours) at Monash University VIC (2014), examining the effect of fibre and short-chain fatty acids in Allergic Bronchopulmonary Aspergillosis and Eosinophilic Oesophagitis.
He completed his PhD at Monash Medical Centre/Monash Univervisty VIC (2019) examining the interplay between the gut microbiome and neutrophils in a mouse model of colitis.
Member of ASI and TSANZ.
Tavel award to the International Congress of Immuology 2016.
Oral presentations at national and international conferences, including World Congress for Microcirculation 2018 (Canada), VIIN Young Investigators Symposium (Victoria), and for Day of Immunology 2016 (Victoria).
Can supervise: YES
- Severe asthma
- Lung cancer
- Intravital microscopy
Galvao, I, Kim, RY, Shen, S, Budden, KF, Vieira, AT & Hansbro, PM 2020, 'Emerging therapeutic targets and preclinical models for severe asthma', EXPERT OPINION ON THERAPEUTIC TARGETS.View/Download from: Publisher's site
Wen, SW, Shim, R, Ho, L, Wanrooy, BJ, Srikhanta, YN, Prame Kumar, K, Nicholls, AJ, Shen, SJ, Sepehrizadeh, T, de Veer, M, Srikanth, VK, Ma, H, Phan, TG, Lyras, D & Wong, CHY 2019, 'Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke.', Aging cell, vol. 18, no. 5.View/Download from: Publisher's site
Bacterial infection a leading cause of death among patients with stroke, with elderly patients often presenting with more debilitating outcomes. The findings from our retrospective study, supported by previous clinical reports, showed that increasing age is an early predictor for developing fatal infectious complications after stroke. However, exactly how and why older individuals are more susceptible to infection after stroke remains unclear. Using a mouse model of transient ischaemic stroke, we demonstrate that older mice (>12 months) present with greater spontaneous bacterial lung infections compared to their younger counterparts (7-10 weeks) after stroke. Importantly, we provide evidence that older poststroke mice exhibited elevated intestinal inflammation and disruption in gut barriers critical in maintaining colonic integrity following stroke, including reduced expression of mucin and tight junction proteins. In addition, our data support the notion that the localized pro-inflammatory microenvironment driven by increased tumour necrosis factor-α production in the colon of older mice facilitates the translocation and dissemination of orally inoculated bacteria to the lung following stroke onset. Therefore, findings of this study demonstrate that exacerbated dysfunction of the intestinal barrier in advanced age promotes translocation of gut-derived bacteria and contributes to the increased risk to poststroke bacterial infection.
Shen, S, Kumar, KP, Stanley, D, Moore, RJ, Thi, THV, Wen, SW, Hickey, MJ & Wong, CHY 2018, 'Invariant Natural Killer T Cells Shape the Gut Microbiota and Regulate Neutrophil Recruitment and Function During Intestinal Inflammation', FRONTIERS IN IMMUNOLOGY, vol. 9.View/Download from: Publisher's site
Thorburn, AN, McKenzie, CI, Shen, S, Stanley, D, Macia, L, Mason, LJ, Roberts, LK, Wong, CHY, Shim, R, Robert, R, Chevalier, N, Tan, JK, Marino, E, Moore, RJ, Wong, L, McConville, MJ, Tull, DL, Wood, LG, Murphy, VE, Mattes, J, Gibson, PG & Mackay, CR 2015, 'Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites', NATURE COMMUNICATIONS, vol. 6.View/Download from: Publisher's site