Currently studying my PhD in Medicinal Chemistry, with a focus on the design, synthesis and evaluation of antibiotics under the supervision of Assoc. Prof. Andrew McDonagh and Prof. Liz Harry.
- Medicinal Chemistry
- Antibiotic development
- Acetylcholinesterase inhibitors
As of July 2019, my current teaching role is for laboratory classes in the following subjects:
- Chemistry 1
- Environmental Chemistry
I have previously taught in the following subjects at UTS:
- Chemistry 2
- Principles of Scientific Practice
- Organic Chemistry 1 and 2
- Strategies in Drug Synthesis
Ung, AT, West, AN, Phillips, MJA & Williams, SG 2016, 'Synthesis of alkaloid-like compounds via the bridging Ritter reactions II', Monatshefte für Chemie - Chemical Monthly, vol. 147, pp. 1737-1746.View/Download from: UTS OPUS or Publisher's site
The bridging Ritter reactions are considered to be efficient synthetic methods rapidly providing access to alkaloid-like compounds in a few steps from inexpensive starting materials. In this manuscript, we report the synthesis of benzo[c]azepine derivatives bearing either amide or hydroxyl groups via the bridging Ritter reactions. These compounds are diastereoisomers of a known AChE inhibitor. All the structures were fully characterised by NMR spectroscopy and high-resolution mass spectrometry. NMR spectral analysis of diastereoisomers has allowed for the relative stereochemistry of the AChE inhibitor to be established.
the process of neurotransmission across the synaptic cleft in neurons. Reversible AChE inhibitors are currently marketed for the treatment of Alzheimer's disease for their ability to slow down the progression of symptom development such as memory loss. An example of a current treatment is Galantamine (Reminyl), an alkaloid derived from the Galanthus Nivalis species2.
Enantiomers of (-)-2 and (-)-3were successfully prepared and screened for AChE inhibitory activity, along with a small library of novel compounds not observed in previous work. Furthermore, the influence of solvent choice was investigated between (R)-limonene and various nitriles under the Bridging Ritter reaction conditions. The concluding results from this project will be presented.