Currently a PhD student within the School of Mathematical and Physical science. My research is focussed around the design, synthesis, characterisation and biological evaluation of potential antibacterial drugs, with a focus on narrow-spectrum anti-chlamydial agents. I have also worked on the development of Acetylcholinesterase inhibitors utilising bicyclic alkaloid-like scaffolds, as well as the synthesis and testing of tricyclic isoquinoline scaffolds as potential antibacterial agents.
- Medicinal Chemistry
- Chemical synthesis
- Antibiotic development
- Acetylcholinesterase inhibitors
- Anti-chlamydial agents
- Serine protease inhibitors
As of Feburary 2020, my current teaching role is for laboratory classes in the following subjects:
- Principles of Scientific practice (60001)
- Organic Chemistry II (New York University)
I have previously taught in the following subjects at UTS:
- Chemistry 1 and 2
- Principles of Scientific Practice
- Organic Chemistry 1 and 2
- Strategies in Drug Synthesis
- Environmental Chemistry
Ung, AT, West, AN, Phillips, MJA & Williams, SG 2016, 'Synthesis of alkaloid-like compounds via the bridging Ritter reactions II', Monatshefte für Chemie - Chemical Monthly, vol. 147, pp. 1737-1746.View/Download from: UTS OPUS or Publisher's site
The bridging Ritter reactions are considered to be efficient synthetic methods rapidly providing access to alkaloid-like compounds in a few steps from inexpensive starting materials. In this manuscript, we report the synthesis of benzo[c]azepine derivatives bearing either amide or hydroxyl groups via the bridging Ritter reactions. These compounds are diastereoisomers of a known AChE inhibitor. All the structures were fully characterised by NMR spectroscopy and high-resolution mass spectrometry. NMR spectral analysis of diastereoisomers has allowed for the relative stereochemistry of the AChE inhibitor to be established.
the process of neurotransmission across the synaptic cleft in neurons. Reversible AChE inhibitors are currently marketed for the treatment of Alzheimer’s disease for their ability to slow down the progression of symptom development such as memory loss. An example of a current treatment is Galantamine (Reminyl), an alkaloid derived from the Galanthus Nivalis species2.
Enantiomers of (-)-2 and (-)-3were successfully prepared and screened for AChE inhibitory activity, along with a small library of novel compounds not observed in previous work. Furthermore, the influence of solvent choice was investigated between (R)-limonene and various nitriles under the Bridging Ritter reaction conditions. The concluding results from this project will be presented.