Dr. Jiayan Liao received her Ph.D. in 2020 from UTS. She is currently a Research Associate under the supervision of Prof. Dayong Jin in the Institute for Biomedical Materials & Devices (IBMD) at the University of Technology Sydney. She has qualification in material chemistry, nanophotonics, and analytical chemistry, as well as research experiences in controlling the growth of rare-earth-doped nanoparticles, surface modification, DNA bioconjugation and single nanoparticle spectroscopy.
Dr. Liao has been the co-author on more than 40 peer-reviewed journal publications, including in Nature Photonics, The Journal of Physical Chemistry Letters and Nano Letters. Her publications have attracted google citations of >500, h-index of 12.
Honor and Awards
2019 Vice Chancellor’s Postgraduate Research Student Conference fund
2016-2019 CSC-UTS Ph.D. scholarship
2014-2015 Outstanding Master’s Thesis
2014 The Graduate National Scholarship
2014 The Special Recognition Award
2014 The Scholarship of Wu Da Guan
2013-2014 The excellent graduate student
2011-2012 Municipal merit student
2011-2012 The excellent Bachelor’s thesis
2009 Winning Prize of the Fourth Mathematical Modelling
2008 The Second-Grade Scholarship
Rear earth doped nanocrystal;
Size and morphology control;
Home-built optical test system operation:
Laser scanning confocal microscope;
Super-resolution structured illumination microscope;
Widefield imaging microscope;
Time-resolved spectrometry and imaging;
Total internal reflection fluorescent microscope
Nanoparticles surface modification;
COVID antigen and RNA tests
Jiayan Liao, International Conference On Nanoscience and Nanotechnology ICCON 2020 (Oral presentation, Brisbane, Australia)
Jiayan Liao, Institute for Biomedical Materials & Devices (IBMD) research Week, 2020 (Oral presentation, Sydney, Australia)
Jiayan Liao, Three Wise Men Winter School on Luminescent Nanothermometry for Biomedical Applications, 2020 (Poster presentation, Madrid, Spain)
Jiayan Liao, International Symposium on Luminescent Materials, Phosphor Safari 2019 (Xiamen, China)
Jiayan Liao, 2014’ Sol-Gel Symposium of China & International Forum, 2014 (Poster presentation, Kunming, China)
UTS-SUStech Joint Research Centre for Biomedical Materials & Devices;
Fluorescence Imaging Group (FIG), Universidad Autonoma de Madrid;
Institut de Recherche de Chimie Paris, Chimie ParisTech-CNRS;
Debye Institute for NanoMaterials Science, Utrecht University;
Van’t Hoff Institute for Molecular Sciences, University of Amsterdam;
The Group of Biophysics and Complex, Georg-August University.
Self-motivated Ph.D. in material chemistry and bio-optics with 8 years of laboratory research experience, specialising in rare earth nanomaterials, fluorescence spectroscopy, optical microscope, surface modification, DNA conjugation, nano-biosensor development and point-of-care detection.
Single nanoparticle spectroscopy;
Liao, J, Jin, D, Chen, C, Li, Y & Zhou, J 2020, 'Helix Shape Power-Dependent Properties of Single Upconversion Nanoparticles', JOURNAL OF PHYSICAL CHEMISTRY LETTERS, vol. 11, no. 8, pp. 2883-2890.View/Download from: Publisher's site
Liu, B, Chen, C, Di, X, Liao, J, Wen, S, Su, QP, Shan, X, Xu, Z-Q, Ju, LA, Mi, C, Wang, F & Jin, D 2020, 'Upconversion Nonlinear Structured Illumination Microscopy', NANO LETTERS, vol. 20, no. 7, pp. 4775-4781.View/Download from: Publisher's site
Zhou, Y, Chen, Y, He, H, Liao, J, Duong, HTT, Parviz, M & Jin, D 2019, 'A homogeneous DNA assay by recovering inhibited emission of rare earth ions-doped upconversion nanoparticles', Journal of Rare Earths, vol. 37, no. 1, pp. 11-18.View/Download from: Publisher's site
© 2018 Chinese Society of Rare Earths Robust and easy-to-use kits specific for a particular DNA sequence are desirable for early detection of diseases. However, the major challenge with these tests is often the background fluorescence artifacts arising from biological species due to employing UV and visible range of light. Here, we have reported a near-infrared (NIR) fluorescence "turn-on" kit based on rare earth ions doped nanoparticles, upconversion nanoparticles (UCNPs), and gold nanoparticles (AuNPs), which forms a fluorescence-quencher pair, brought together by a hairpin structure through the formation of double-stranded DNA (dsDNA), with quenched upconversion luminescence. In the presence of analytes, the molecular beacon opens to push AuNPs away from UCNPs, with a distance longer than the efficient quenching distance, so that the inhibited upconversion emission will be restored. We demonstrated that this assay provides a homogeneous, facile, simple and highly selective HIV-1 based DNA detection system with restore efficiency up to 85%, and the detection limit of 5 nm.
Zhou, J, Wen, S, Liao, J, Clarke, C, Tawfik, SA, Ren, W, Mi, C, Wang, F & Jin, D 2018, 'Activation of the surface dark-layer to enhance upconversion in a thermal field', Nature Photonics, vol. 12, no. 3, pp. 154-158.View/Download from: Publisher's site
© 2018 The Author(s). Thermal quenching, in which light emission experiences a loss with increasing temperature, broadly limits luminescent efficiency at higher temperature in optical materials, such as lighting phosphors1-3and fluorescent probes4-6. Thermal quenching is commonly caused by the increased activity of phonons that leverages the non-radiative relaxation pathways. Here, we report a kind of heat-favourable phonons existing at the surface of lanthanide-doped upconversion nanomaterials to combat thermal quenching. It favours energy transfer from sensitizers to activators to pump up the intermediate excited-state upconversion process. We identify that the oxygen moiety chelating Yb3+ions, [Yb···O], is the key underpinning this enhancement. We demonstrate an approximately 2,000-fold enhancement in blue emission for 9.7 nm Yb3+-Tm3+co-doped nanoparticles at 453 K. This strategy not only provides a powerful solution to illuminate the dark layer of ultra-small upconversion nanoparticles, but also suggests a new pathway to build high-efficiency upconversion systems.
He, H, Liu, B, Wen, S, Liao, J, Lin, G, Zhou, J & Jin, D 2018, 'Quantitative Lateral Flow Strip Sensor Using Highly Doped Upconversion Nanoparticles.', Analytical chemistry, vol. 90, no. 21, pp. 12356-12360.View/Download from: Publisher's site
Paper-based lateral flow assays, though being low-cost and widely used for rapid in vitro diagnostics, are indicative and do not provide sufficient sensitivity for the detection and quantification of low abundant biomarkers for early stage cancer diagnosis. Here, we design a compact device to create a focused illumination spot with high irradiance, which activates a range of highly doped 50 nm upconversion nanoparticles (UCNPs) to produce orders of magnitude brighter emissions. The device employs a very low-cost laser diode, simplified excitation, and collection optics and permits a mobile phone camera to record the results. Using highly erbium ion (Er3+)-doped and thulium ion (Tm3+)-doped UCNPs as two independent reporters on two-color lateral flow strips, new records of limit of detection (LOD), 89 and 400 pg/mL, have been achieved for the ultrasensitive detection of prostate specific antigen (PSA) and ephrin type-A receptor 2 (EphA2) biomarkers, respectively, without crosstalk. The technique and device presented in this work suggests a broad scope of low-cost, rapid, and quantitative lateral flow assays in early detection of bioanalytes.
Liao, J, Yang, Z, Shao, B, Li, J, Qiu, J, Song, Z & Yang, Y 2016, 'Preparation and photoluminescence modification of NaGdF4:Eu3+ nanorods in a crystalline colloidal array', Science of Advanced Materials, vol. 8, no. 4, pp. 697-702.View/Download from: Publisher's site
© 2016 by American Scientific Publishers. A crystalline colloidal array was prepared by an ion exchange method, and its structure was characterized. Eu3+ doped NaGdF4 nanorods were added into the crystalline colloidal array, leading to an ordered crystalline colloidal array including the nanorods. The photoluminescence properties of NaGdF4:Eu3+ nanorods in the array were investigated. A significant suppression of photoluminescence of NaGdF4:Eu3+ nanorods in the range of the photonic band gap was observed.
Liao, J, Yang, Z, Sun, J, Lai, S, Shao, B, Li, J, Qiu, J, Song, Z & Yang, Y 2015, 'Preparation and Upconversion Emission Modification of Crystalline Colloidal Arrays and Rare Earth Fluoride Microcrystal Composites', Scientific Reports, vol. 5.View/Download from: Publisher's site
In this paper, highly ordered crystalline colloidal arrays containing rare earth fluoride microcrystals were fabricated. The upconversion emission property of rare earth fluoride microcrystals in crystalline colloidal arrays was studied and modified. A significant suppression and enhancement of the upconversion emission from the rare earth fluorides can be observed in the regions of the photonic band gap and its band edge, respectively. The suppression or enhancement factor was shown to be related to the ordered degree of the crystalline colloidal arrays and is critical in the preparation of upconversion displays and low-threshold lasers.
Yang, ZW, Wang, YD, Liao, JY, Yang, JZ, Qiu, JB & Song, ZG 2015, 'Upconversion Emission Modification and White Light Generation in NaYF4:Yb3+, Er3+, Tm3+ Nanocrystals/Opal Photonic Crystal Composites', IEEE Photonics Journal, vol. 7, no. 6.View/Download from: Publisher's site
© 2009-2012 IEEE. In this paper, we fabricated NaYF4:Yb3+, Er3+, Tm3+ nanocrystal/opal photonic crystal composites by depositing NaYF4:Yb3+, Er3+, Tm3+ nanocrystals on the surface of opal photonic crystals, and we investigated the influence of photonic bandgaps on upconversion (UC) emission properties of NaYF4:Yb 3+, Er3+, Tm3+ nanocrystals. When the photonic bandgaps overlapped with the UC emission bands of NaYF4:Yb 3+, Er3+, Tm3+ nanocrystals on the opal photonic crystal surfaces, the suppression or enhancement of UC emissions was observed due to the Bragg reflection effect of photonic crystal, resulting in the modification of red, green, and blue UC emissions. Thus, white UC emission was realized.
Liao, J, Yang, Z, Wu, H, Lai, S, Qiu, J, Song, Z, Yang, Y & Yin, Z 2014, 'Continuous modification of upconversion luminescence of fluorescent dye in the crystalline colloidal arrays', Colloid and Polymer Science, vol. 292, no. 3, pp. 613-617.View/Download from: Publisher's site
The crystalline colloidal arrays with controllable photonic bandgaps were prepared by the change of volume fraction of the polystyrene microspheres. Upconversion emission property of fluorescent dye has investigated in crystalline colloidal array, and continuous modification of the upconversion emission of fluorescent dye was observed. A significant suppression of upconversion emission of dye in the range of the photonic bandgap as well as enhancement at the bandgap edge was obtained in the crystalline colloidal arrays. In addition, upconversion emission of dye was also enhanced when the excited light overlapped with the long or short bandgap edge of the crystalline colloidal arrays, which is due to slow photons effect near the edges of a photonic bandgap. The continuous modification and enhancement of upconversion emission may be important for the development of low-threshold upconversion lasers and displays. © 2013 Springer-Verlag.
Liao, J, Yang, Z, Wu, H, Lai, S, Qiu, J, Song, Z, Yang, Y, Zhou, D & Yin, Z 2014, 'Upconversion luminescence enhancement of NaYF4: Yb3+, Er3+ nanoparticles on inverse opal surface', Surface Review and Letters, vol. 21, no. 1.View/Download from: Publisher's site
LaPO4 inverse opal photonic crystals with different photonic band gaps were fabricated by template-assisted method. The Yb 3+/Er3+ co-doped NaYF4 nanoparticles were deposited on the surfaces of the inverse opals, and their up-conversion emission properties were investigated. The upconversion emissions of Yb 3+/Er3+ co-doped NaYF4 nanoparticles on the inverse opal surfaces have been enhanced when the upconversion emission bands of the nanoparticles are in the range of photonic band gaps of the inverse opals, which is attributed to an efficient and selective reflection of photonic band gaps. © 2014 World Scientific Publishing Company.
Yang, Y, Liao, J, Yang, Z, Lai, S, Shao, B, Li, J, Qiu, J & Song, Z 2014, 'Upconversion emission enhancement of NaYF4:Yb,Er nanoparticles by coupling silver nanoparticle plasmons and photonic crystal effects', Journal of Physical Chemistry C, vol. 118, no. 31, pp. 17992-17999.View/Download from: Publisher's site
Metal nanoparticle plasmons or the photonic crystal effect are being widely used to modify luminescence properties of materials. However, coupling of surface plasmons with photonic crystals are seldom reported for enhancing luminescence of materials. In this paper, a new method for upconversion emission enhancement of rare-earth doped nanoparticles is reported, attributed to the coupling of surface plasmons with photonic band gap effects. Opal/Ag hybrid substrates were prepared by depositing Ag nanoparticles on the top layer of opals by magnetron sputtering. The selective enhancement of red or green upconversion emission of NaYF4:Yb3+,Er3+ nanoparticles on the opal/Ag hybrid substrates is attributed to the coupling effect of surface plasmons and Bragg reflection of the photonic band gap. In addition, the upconversion emission enhancement of NaYF4:Yb 3+,Er3+ nanoparticles on the opal/Ag hybrid substrate is attributed to the excitation enhancement was obtained when the excitation light wavelengths overlap with the photonic band gaps of opal/Ag hybrid substrates. We believe that these enhancement effects based on the coupling of metal nanoparticles with the photonic band gap could be extended to other light-emitting materials, which may result in a new generation of lighting devices. © 2014 American Chemical Society.
Liao, J, Yang, Z, Wu, H, Yan, D, Qiu, J, Song, Z, Yang, Y, Zhou, D & Yin, Z 2013, 'Enhancement of the up-conversion luminescence of Yb3+/Er 3+ or Yb3+/Tm3+ co-doped NaYF4 nanoparticles by photonic crystals', Journal of Materials Chemistry C, vol. 1, no. 40, pp. 6541-6546.View/Download from: Publisher's site
A new method for enhancing the upconversion (UC) emission of rare-earth doped nanoparticles is reported, in which Yb3+/Er3+ or Yb3+/Tm3+ co-doped NaYF4 nanoparticles are deposited on to the surface of photonic crystal (PC) films. The UC emission of the Yb3+/Er3+ or Yb3+/Tm3+ co-doped NaYF4 nanoparticles on the PC surface was notably enhanced when the UC emission bands of the Yb3+/Er3+ or Yb 3+/Tm3+ co-doped NaYF4 nanoparticles were within the range of the photonic band gap of the PCs, indicating that the PCs were efficient and selective reflection mirrors. The results show that PCs may have potential applications in UC optoelectronics and lighting devices. © 2013 The Royal Society of Chemistry.