Dr Jiao Jiao Li (JJ) is a biomedical engineer, NHMRC Early Career Fellow, and a chief investigator on the ARC Training Centre for Innovative BioEngineering. She received her PhD from the University of Sydney in 2015. JJ is researching regenerative medicine approaches to treat chronic musculoskeletal conditions such as osteoarthritis and bone loss. She has particular interest in developing stem cell-based therapeutics, as well as biomaterials for tissue engineering.
JJ has led interdisciplinary projects in basic science and clinical research relating to regenerative medicine and orthopaedics. She has received two institutional best manuscript awards (Rebecca Cooper Medal 2017, Institute of Bone and Joint Research Award 2019) and the 2019 Young Investigator Award from the Australasian Wound & Tissue Repair Society (AWTRS). One of her publications (J Mater Chem B 2015) from a collaboration with Tufts University she established during her Endeavour Research Fellowship (2011) was publicised as a Science Highlight article by the NIH. She has delivered >40 conference presentations and received >15 best presentation awards. She is a co-inventor on a patent granted in Australia, Japan, Europe and USA. She was selected from internationally competitive applicants to join the Osteoarthritis Research Society International (OARSI) Young Investigator Committee in 2019, and the Tissue Engineering journal Young Investigator Council in 2016.
JJ is also an Honorary Associate at the Kolling Institute, Faculty of Medicine and Health, and at the School of Biomedical Engineering, Faculty of Engineering, both at the University of Sydney.
Research grants and fellowships
- NHMRC Early Career Fellowship (APP1120249). 2017–. Sole CI.
- ARC Industrial Transformation Training Centre (IC170100022). 2018–. ARC Training Centre for Innovative BioEngineering. Co-CI.
- The Lincoln Centre Project Grant. 2020–2021. Lead CI.
- Arthritis Australia Suzette Gateby Grant-in-Aid. 2020–2021. Lead CI.
- University of Sydney–Shanghai Jiao Tong University (USYD-SJTU) Partnership Collaboration Award. 2019–2020. Lead CI.
- University of Sydney, Lifespan Seed Grant. 2019. Lead CI.
- University of Sydney, China Studies Centre Small Project Grant. 2019. Sole CI.
- Arthritis Australia & State/Territory Affiliate Grant. 2018. Lead CI.
- University of Sydney, Sydney Medical School Kick Start Grant. 2018. Sole CI.
- University of Sydney, Sydney Medical School–Faculty of Engineering & Information Technologies (SMS-FEIT) Biomedical Engineering Research Collaboration Scheme. 2018. Lead CI.
- Endeavour Research Fellowship. 2011. Sole CI. Awarded to undertake research at Tufts University, USA for 6 months, hosted by Prof David Kaplan.
Invited speaker addresses and conference presentations
International: Tsinghua University (2019), Shanghai Jiao Tong University (2019), National University of Ireland Galway (2018). National: Sydney Eye Hospital (2018). Institutional: UTS School of Biomedical Engineering Seminar Series (2020), Sydney Early-Mid Career Academic Network (SEMCAN) special seminar (2020); China Studies Centre (CSC) Research Forum (2019); Applied/Plasma Group Research Seminars hosted by the School of Physics (2019); Institute of Bone and Joint Research (IBJR) Seminars (2019).
Notable international conferences:
- Osteoarthritis Research Society International (OARSI) World Congress (2020-cancelled due to COVID-19, 2019)
- Tissue Engineering & Regenerative Medicine International Society (TERMIS) (World Congress 2018; Asia-Pacific chapter 2019, 2016, 2013; Americas chapter 2011, 2010)
- 8th World Congress of Biomechanics (2018)
- 9th World Biomaterials Congress (2012)
Notable national conferences:
- Australian Society for Medical Research (ASMR) (2019, 2018, 2017)
- Australian & New Zealand Orthopaedic Research Society (ANZORS) (2019, 2018, 2017, 2016, 2013, 2012)
- Matrix Biology Society of Australia & New Zealand (MBSANZ) (2018)
- New Horizons (2019, 2018, 2017)
- Alliance for Design and Application in Tissue Engineering (ADATE) (2016-international, 2014, 2012, 2010)
- Invited speaker for the 2017 Bosch Institute Annual Scientific Meeting
Session chair: International – TERMIS: Symposium Organiser and Chair (2021); Young Investigator Co-chair (2018, 2016). National – ANZORS (2019-keynote session, 2018-podium session); New Horizons (2019, 2018).
Awards and honours
- 2019 Young Investigator Award, Australasian Wound & Tissue Repair Society (AWTRS).
- 2019 Institute of Bone and Joint Research (IBJR) Basic Science Manuscript Award.
- 2017 Rebecca L. Cooper Medical Research Foundation Medal.
- 2016 Award of Excellence by the Institute of Biomedical Engineering and Technology, University of Sydney.
- 2011 Endeavour Research Fellowship, awarded by the Australian Government to undertake research at Tufts University for 6 months.
- 2010 6-Degrees of Freedom Award by the Sydney Orthopaedic Research Institute (SORI) for the top undergraduate thesis in Biomedical Engineering.
- 2010 University Medal, Bachelor of Engineering (Mechanical Engineering) (Biomedical) / Bachelor of Medical Science.
Awards for conference presentations (17): International: 2nd Prize, Young Investigators “3 Minutes Speech” Competition (OARSI China Evening 2019); Student & Young Investigator Section Oral Award (TERMIS-AP 2016). National/State: Award for Research Excellence (ASMR NSW 2018); ECR Oral Presentation Award (New Horizons 2019, 2018, 2017); Award for Best Doctoral Presentation (ADATE 2014, 2010); Award for Best PhD Presentation (ANZORS 2013). Institutional: First Prize for Best Presentation (Sydney Medical School ECR Showcase 2017); Prize for Best Postgraduate Poster (USYD Research Conversazione 2014, 2013, 2012, 2010); Prizes (2) for Best Presentation (USYD Student Research Conference 2012); Award for Outstanding Oral Presentation (USYD Bosch Young Investigators Symposium 2012).
Notable travel grants (total 13): Ramsay Health Care Travel Fellowship (2019, 2018); Institute of Bone and Joint Research Travel Award (2018); Kolling Institute ECR Travelling Fellowship (2018).
Professional and leadership activities
- Grant review panels: ECR Observer, NHMRC Ideas Grants (2019). Science Assessing Committee for Project Grant EOIs, Health Research Council of New Zealand (2017; invited to New Zealand for panel discussion and was primary spokesperson for 3 grants).
- Grant assessment: Scientific Expert Peer Reviewer, NHMRC Development Grants (2020: 10, 2019: 7, 2018: 5). Assessor for NHMRC Project Grants (2018: 2), ARC Discovery Projects (2020: 1, 2019: 2, 2018: 1), ARC DECRA (2018: 1). Assessor for international grants: ANR France (2019: 1), MRC UK (2020: 1, 2019: 1), Arthritis Research UK (2017: 1). Reviewer Panel, Ramsay Research and Teaching Fund Projects (2018: 18).
- Journals: Editorial Board member of Tissue Engineering (2016–2019). Reviewer Board of Biomolecules (2019–now). Outstanding Reviewer for Biomaterials Science (2019) and invited reviewer for >30 multidisciplinary journals, including prominent journals in my field: Advanced Healthcare Materials, Journal of Materials Chemistry B, Annals of the Rheumatic Diseases, ACS Biomaterials Science & Engineering, ACS Applied Materials & Interfaces.
- Conference scientific committee: ASMR NSW (2019); ANZORS (2019, 2018); New Horizons (2019, 2018).
Committee roles for scientific societies:
- Osteoarthritis Research Society International (OARSI) Young Investigator Committee (2019–2023).
- Young Investigator Council and Editorial Board of Tissue Engineering, Parts A, B, & C (2016–2019).
- Australian Academy of Science EMCR Forum Representative Network (2020–2021).
- Australian Society for Medical Research (ASMR) NSW Committee (2019–2020).
- Royal North Shore Hospital Scientific Staff Council Deputy Chair (2019) and Executive Committee (2018–2019).
- Sydney Nano ECR Ambassador (2019–now).
- Convenor, ASMR NSW Early Career Development Day (2019). Held on 18 Sep 2019 at the University of Sydney; sold out with 120 attendees.
- Co-convenor, ‘Personal journeys along the road of translation’ symposium (2019). With Prof Hala Zreiqat (USYD) and Prof Fiona Wood (UWA), held on 3 Dec 2019 at the University of Sydney; attended by distinguished guests (Governor of NSW, USYD Vice-Chancellor and Deputy Vice-Chancellor (Research)).
- Organising Committee, New Horizons conference (2020, 2019, 2018).
- Organising Committee, Kolling Institute Seminar Series (2017–2018).
- Organising Committee, ADATE Symposia (2016, 2014, 2012).
Community engagement and media:
- Invited speaker, Science in the Swamp – Centennial Parklands (18 August 2019).
- Invited speaker, Careers Day at North Sydney Girls High School (2020, 2019, 2018) and Sydney Girls High School (2019).
- Executive committee, BIOTech Futures Program (2019–now). Held by ARC Training Centre for Innovative BioEngineering.
- Invited speaker, ‘Sydney Science Experience’ (2019). Held by Faculty of Science, University of Sydney.
- Mentor, Science Extension Program (2018–now). Held by Faculty of Science, University of Sydney
- Kolling Institute School Partnership Program (2018).
- Featured on the Einstein A Go-Go radio program, 3RRR Digital (102.7FM) for 20 PhDs in 20 minutes Postdoc edition, hosted by Dr Shane Huntington, live broadcast on 5 July 2020.
- Research profile published on the Women in STEMM Australia website (7 Jul 2020).
- Co-author on a magazine article published by the American Orthotic and Prosthetic Association (AOPA): O&P News, July 2018, p. 12-15.
- Co-author on an article “Tissue Engineering”, published in Issue 7 (March 2017) of the Inside Enterprise magazine.
- Published research (Li JJ et al, J Mater Chem B 2015, 3(26):5361) was publicised as a Science Highlight by the U.S. National Institute of Biomedical Imaging and Bioengineering (16 September 2015).
Can supervise: YES
- Tissue engineering and regenerative medicine
- Stem cells, extracellular vesicles, microenvironment
- Osteoarthritis, musculoskeletal tissues, orthopaedics
Xu, Z, Xia, Y, Zhou, P, Li, JJ, Yang, M, Zhang, Y, Zhang, Y, Xie, Y, Li, L, Pan, H, Xu, S & Wang, G 2021, 'Silicon incorporation into hydroxyapatite nanocarrier counteracts the side effects of vancomycin for efficient chronic osteomyelitis treatment', Chemical Engineering Journal, vol. 406, pp. 126821-126821.View/Download from: Publisher's site
Guo, A, Wang, B, Lyu, C, Li, W, Wu, Y, Zhu, L, Bi, R, Huang, C, Li, JJ & Du, Y 2020, 'Consistent apparent Young's modulus of human embryonic stem cells and derived cell types stabilized by substrate stiffness regulation promotes lineage specificity maintenance.', Cell regeneration (London, England), vol. 9, no. 1, p. 15.View/Download from: Publisher's site
BACKGROUND:Apparent Young's modulus (AYM), which reflects the fundamental mechanical property of live cells measured by atomic force microscopy and is determined by substrate stiffness regulated cytoskeletal organization, has been investigated as potential indicators of cell fate in specific cell types. However, applying biophysical cues, such as modulating the substrate stiffness, to regulate AYM and thereby reflect and/or control stem cell lineage specificity for downstream applications, remains a primary challenge during in vitro stem cell expansion. Moreover, substrate stiffness could modulate cell heterogeneity in the single-cell stage and contribute to cell fate regulation, yet the indicative link between AYM and cell fate determination during in vitro dynamic cell expansion (from single-cell stage to multi-cell stage) has not been established. RESULTS:Here, we show that the AYM of cells changed dynamically during passaging and proliferation on substrates with different stiffness. Moreover, the same change in substrate stiffness caused different patterns of AYM change in epithelial and mesenchymal cell types. Embryonic stem cells and their derived progenitor cells exhibited distinguishing AYM changes in response to different substrate stiffness that had significant effects on their maintenance of pluripotency and/or lineage-specific characteristics. On substrates that were too rigid or too soft, fluctuations in AYM occurred during cell passaging and proliferation that led to a loss in lineage specificity. On a substrate with 'optimal' stiffness (i.e., 3.5 kPa), the AYM was maintained at a constant level that was consistent with the parental cells during passaging and proliferation and led to preservation of lineage specificity. The effects of substrate stiffness on AYM and downstream cell fate were correlated with intracellular cytoskeletal organization and nuclear/cytoplasmic localization of YAP. CONCLUSIONS:In summary, this study suggests that optimal sub...
Huang, P, Huang, Y, Li, JJ, Li, Y, Luo, K, Tang, G, Tang, L, Wu, Y-L, Yang, Z & Yu, B 2020, 'Outstanding Reviewers for Biomaterials Science in 2019', BIOMATERIALS SCIENCE, vol. 8, no. 9, pp. 2343-2343.View/Download from: Publisher's site
Li, J & Little, C 2020, 'AN IN VITRO STUDY TO INVESTIGATE THE EFFECTS OF STEM CELL THERAPY FOR TREATING OSTEOARTHRITIS', OSTEOARTHRITIS AND CARTILAGE, vol. 28, pp. S503-S504.
Xing, D, Liu, W, Li, JJ, Liu, L, Guo, A, Wang, B, Yu, H, Zhao, Y, Chen, Y, You, Z, Lyu, C, Li, W, Liu, A, Du, Y & Lin, J 2020, 'Engineering 3D functional tissue constructs using self-assembling cell-laden microniches', Acta Biomaterialia, vol. 114, pp. 170-182.View/Download from: Publisher's site
© 2020 Tissue engineering using traditional size fixed scaffolds and injectable biomaterials are faced with many limitations due to the difficulties of producing macroscopic functional tissues. In this study, 3D functional tissue constructs were developed by inducing self-assembly of microniches, which were cell-laden gelatin microcryogels. During self-assembly, the accumulation of extracellular matrix (ECM) components was found to strengthen cell-cell and cell-ECM interactions, leading to the construction of a 'native' microenvironment that better preserved cell viability and functions. MSCs grown in self-assembled constructs showed increased maintenance of stemness, reduced senescence and improved paracrine activity compared with cells grown in individual microniches without self-assembly. As an example of applying the self-assembled constructs in tissue regeneration, the constructs were used to induce in vivo articular cartilage repair and successfully regenerated hyaline-like cartilage tissue in the absence of other extrinsic factors. This unique approach of developing self-assembled 3D functional constructs holds great promise for the generation of tissue engineered organoids and repair of challenging tissue defects. Statement of Significance: We developed 3D functional tissue constructs using a unique gelatin-based microscopic hydrogel (microcryogels). Mesenchymal stem cells (MSCs) were loaded into gelatin microcryogels to form microscopic cell-laden units (microniches), which were induced to undergo self-assembly using a specially designed 3D printed frame. Extracellular matrix accumulation among the microniches resulted in self-assembled macroscopic constructs with superior ability to maintain the phenotypic characteristics and stemness of MSCs, together with the suppression of senescence and enhanced paracrine function. As an example of application in tissue regeneration, the self-assembled constructs were shown to successfully repair articular cartilage...
Xing, D, Liu, W, Wang, B, Li, JJ, Zhao, Y, Li, H, Liu, A, Du, Y & Lin, J 2020, 'Intra-articular Injection of Cell-laden 3D Microcryogels Empower Low-dose Cell Therapy for Osteoarthritis in a Rat Model.', Cell transplantation, vol. 29, p. 963689720932142.View/Download from: Publisher's site
Intra-articular injection of mesenchymal stem cells (MSCs) in an osteoarthritic joint can help slow down cartilage destruction. However, cell survival and the efficiency of repair are generally low due to mechanical damage during injection and a high rate of cell loss. We, thus, investigated an improved strategy for cell delivery to an osteoarthritic joint through the use of three-dimensional (3D) microcryogels. MSCs were seeded into 3D microcryogels. The viability and proliferation of MSCs in microcryogels were determined over 5 d, and the phenotype of MSCs was confirmed through trilineage differentiation tests and flow cytometry. In Sprague Dawley rats with induced osteoarthritis (OA) of the knee joint, a single injection was made with the following groups: saline control, low-dose free MSCs (1 × 105 cells), high-dose free MSCs (1 × 106 cells), and microcryogels + MSCs (1 × 105 cells). Cartilage degeneration was evaluated by macroscopic examination, micro-computed tomographic analysis, and histology. MSCs grown in microcryogels exhibited optimal viability and proliferation at 3 d with stable maintenance of phenotype in vitro. Microcryogels seeded with MSCs were, therefore, primed for 3 d before being used for in vivo experiments. At 4 and 8 wk, the microcryogels + MSCs and high-dose free MSC groups had significantly higher International Cartilage Repair Society macroscopic scores, histological evidence of more proteoglycan deposition and less cartilage loss accompanied by a lower Mankin score, and minimal radiographic evidence of osteoarthritic changes in the joint compared to the other two groups. In conclusion, intra-articular injection of cell-laden 3D microcryogels containing a low dose of MSCs can achieve similar effects as a high dose of free MSCs for OA in a rat model. Primed MSCs in 3D microcryogels can be considered as an improved delivery strategy for cell therapy in treating OA that minimizes cell dose while retaining therapeutic efficacy.
Xing, D, Wu, J, Wang, B, Liu, W, Liu, W, Zhao, Y, Wang, L, Li, JJ, Liu, A, Zhou, Q, Hao, J & Lin, J 2020, 'Intra-articular delivery of umbilical cord-derived mesenchymal stem cells temporarily retard the progression of osteoarthritis in a rat model', INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, vol. 23, no. 6, pp. 778-787.View/Download from: Publisher's site
Yan, L, Li, JJ, Zhu, Y, Liu, H, Liu, R, Zhao, B & Wang, B 2020, 'Interference screws are more likely to perform better than cortical button and cross-pin fixation for hamstring autograft in ACL reconstruction: a Bayesian network meta-analysis', KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY.View/Download from: Publisher's site
Yang, Y, Xing, D, Wang, Y, Jia, H, Li, B & Li, JJ 2020, 'A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway', BMC MOLECULAR AND CELL BIOLOGY, vol. 21, no. 1.View/Download from: Publisher's site
Zhao, Y, You, Z, Xing, D, Li, JJ, Zhang, Q, Huang, H, Li, Z, Jiang, S, Wu, Z, Zhang, Y, Li, W, Zhang, L, Du, Y & Lin, J 2020, 'Comparison of chondrocytes in knee osteoarthritis and regulation by scaffold pore size and stiffness.', Tissue engineering. Part A.View/Download from: Publisher's site
BACKGROUND:In knee osteoarthritis (OA), there is more pronounced cartilage damage in the medial compartment ('lesion zone') than the lateral compartment ('remote zone'). This study fills a gap in the literature by conducting a systematic comparison of cartilage and chondrocyte characteristics from these two zones. It also investigates whether chondrocytes from the different zones respond distinctly to changes in the physical and mechanical microenvironment using 3D porous scaffolds by changing stiffness and pore size. METHODS:Cartilage was harvested from patients with end-stage varus knee OA. Cartilage from the lesion and remote zones were compared through histological and biomechanical assessments, as well as proteomic and gene transcription analyses of chondrocytes. Gelatin scaffolds with varied pore sizes and stiffness were used to investigate in vitro microenvironmental regulation of chondrocytes from the two zones. RESULTS:Cartilage from the lesion and remote zones differed significantly (P<0.05) in histological and biomechanical characteristics, as well as phenotype, protein and gene expression of chondrocytes. Chondrocytes from both zones were sensitive to changes in the structural and mechanical properties of gelatin scaffolds. Interestingly, while all chondrocytes better retained chondrocyte phenotype in stiffer scaffolds, those from the lesion and remote zones respectively preferred scaffolds with larger and smaller pores. CONCLUSIONS:Distinct variations exist in cartilage and chondrocyte characteristics in the lesion and remote zones of knee OA. Cells in these two zones respond differently to variations in the physical and mechanical microenvironment. Understanding and manipulating these differences will facilitate the development of more efficient and precise diagnostic and therapeutic approaches for knee OA.
Zhu, Y, Li, JJ, Reng, J, Wang, S, Zhang, R & Wang, B 2020, 'Global trends of Pseudomonas aeruginosa biofilm research in the past two decades: A bibliometric study', MICROBIOLOGYOPEN, vol. 9, no. 6.View/Download from: Publisher's site
Li, J & Little, C 2019, 'ROLE OF STEM CELLS AND BIOACTIVE SCAFFOLD IN CHRONIC JOINT INJURY: WORKING TOWARDS A REGENERATIVE MEDICINE APPROACH TO STOP OSTEOARTHRITIS PROGRESSION', OSTEOARTHRITIS AND CARTILAGE, vol. 27, pp. S82-S83.View/Download from: Publisher's site
Li, JJ, Dunstan, CR, Entezari, A, Li, Q, Steck, R, Saifzadeh, S, Sadeghpour, A, Field, JR, Akey, A, Bell, DC, Vielreicher, M, Friedrich, O, Roohani-Esfahani, S-I & Zreiqat, H 2019, 'A Novel Bone Substitute with High Bioactivity, Strength, and Porosity for Repairing Large and Load-Bearing Bone Defects (vol 8, 1801298, 2019)', ADVANCED HEALTHCARE MATERIALS, vol. 8, no. 13.View/Download from: Publisher's site
Li, JJ, Dunstan, CR, Entezari, A, Li, Q, Steck, R, Saifzadeh, S, Sadeghpour, A, Field, JR, Akey, A, Vielreicher, M, Friedrich, O, Roohani-Esfahani, S & Zreiqat, H 2019, 'A Novel Bone Substitute with High Bioactivity, Strength, and Porosity for Repairing Large and Load-Bearing Bone Defects', ADVANCED HEALTHCARE MATERIALS, vol. 8, no. 8.View/Download from: Publisher's site
Li, JJ, Hosseini-Beheshti, E, Grau, GE, Zreiqat, H & Little, CB 2019, 'Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis', NANOMATERIALS, vol. 9, no. 2.View/Download from: Publisher's site
Thomson, S, Lu, W, Zreiqat, H, Li, JJ, Tetsworth, K & Al Muderis, M 2019, 'Proximal Bone Remodeling in Lower Limb Amputees Reconstructed With an Osseointegrated Prosthesis', JOURNAL OF ORTHOPAEDIC RESEARCH, vol. 37, no. 12, pp. 2524-2530.View/Download from: Publisher's site
Wang, B, Xing, D, Li, JJ, Zhu, Y, Dong, S & Zhao, B 2019, 'Lateral or medial approach for valgus knee in total knee arthroplasty-which one is better? A systematic review', JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol. 47, no. 11, pp. 5400-5413.View/Download from: Publisher's site
Al Muderis, MM, Lu, WY, Li, JJ, Kaufman, K, Orendurff, M, Highsmith, MJ, Lunseth, PA & Kahle, JT 2018, 'Clinically Relevant Outcome Measures Following Limb Osseointegration; Systematic Review of the Literature', JOURNAL OF ORTHOPAEDIC TRAUMA, vol. 32, no. 2, pp. E64-E75.View/Download from: Publisher's site
Li, JJ, Akey, A, Dunstan, CR, Vielreicher, M, Friedrich, O, Bell, DC & Zreiqat, H 2018, 'Effects of Material-Tissue Interactions on Bone Regeneration Outcomes Using Baghdadite Implants in a Large Animal Model', ADVANCED HEALTHCARE MATERIALS, vol. 7, no. 15.View/Download from: Publisher's site
Li, JJ, Ebied, M, Xu, J & Zreiqat, H 2018, 'Current Approaches to Bone Tissue Engineering: The Interface between Biology and Engineering', ADVANCED HEALTHCARE MATERIALS, vol. 7, no. 6.View/Download from: Publisher's site
Al Muderis, M, Lu, W & Li, JJ 2017, 'Osseointegrated Prosthetic Limb for the treatment of lower limb amputations. Experience and outcomes', UNFALLCHIRURG, vol. 120, no. 4, pp. 306-310.View/Download from: Publisher's site
Al Muderis, M, Lu, W, Tetsworth, K, Bosley, B & Li, JJ 2017, 'Single-stage osseointegrated reconstruction and rehabilitation of lower limb amputees: the Osseointegration Group of Australia Accelerated Protocol-2 (OGAAP-2) for a prospective cohort study', BMJ OPEN, vol. 7, no. 3.View/Download from: Publisher's site
Atallah, R, Li, JJ, Lu, W, Leijendekkers, R, Frolke, JP & Al Muderis, M 2017, 'Osseointegrated Transtibial Implants in Patients with Peripheral Vascular Disease A Multicenter Case Series of 5 Patients with 1-Year Follow-up', JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, vol. 99, no. 18, pp. 1516-1523.View/Download from: Publisher's site
Li, JJ, Roohani-Esfahani, S-I, Kim, K, Kaplan, DL & Zreiqat, H 2017, 'Silk coating on a bioactive ceramic scaffold for bone regeneration: effective enhancement of mechanical and in vitro osteogenic properties towards load-bearing applications', JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 11, no. 6, pp. 1741-1753.View/Download from: Publisher's site
Mills, N, Lu, W, Li, JJ & Al Muderis, M 2017, 'Osseointegration as treatment for a knee disarticulation because of a congenital femoral deficiency: A case report', JBJS Case Connector, vol. 7, no. 4.View/Download from: Publisher's site
© 2017 By The Journal Of Bone And Joint Surgery, Incorporated. Case: A 25-year-old woman underwent osseointegration surgery as treatment for an amputation that had been performed because of congenital femoral deficiency. The undersized custom-designed implant for the congenitally hypoplastic femur subsequently loosened, causing substantial pain and loss of function. The patient underwent revision surgery with a larger standard-sized osseointegration implant, and experienced no additional complications. Conclusion: This case demonstrates the possibility of stimulating a hypertrophic response in underdeveloped bone, which allows the subsequent insertion of a larger implant with greater stability. Similar procedures can be considered for the treatment of patients who had amputations because of congenital deficiencies, in order to produce improved outcomes and reduce the risk of additional complications.
Wang, L, Yang, Q, Chen, Y, Chai, Y, Li, JJ, Du, L, Tan, R, Yang, S, Tu, M & Yu, B 2017, 'A reformative shear precipitation procedure for the fabrication of vancomycin-loaded poly(lactide-co-glycolide) microspheres', JOURNAL OF BIOMATERIALS APPLICATIONS, vol. 31, no. 7, pp. 995-1009.View/Download from: Publisher's site
Chen, Y, Zhou, Y, Yang, S, Li, JJ, Li, X, Ma, Y, Hou, Y, Jiang, N, Xu, C, Zhang, S, Zeng, R, Tu, M & Yu, B 2016, 'Novel bone substitute composed of chitosan and strontium-doped alpha-calcium sulfate hemihydrate: Fabrication, characterisation and evaluation of biocompatibility', MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol. 66, pp. 84-91.View/Download from: Publisher's site
Li, JJ, Roohani-Esfahani, S-I, Dunstan, CR, Quach, T, Steck, R, Saifzadeh, S, Pivonka, P & Zreiqat, H 2016, 'Efficacy of novel synthetic bone substitutes in the reconstruction of large segmental bone defects in sheep tibiae', BIOMEDICAL MATERIALS, vol. 11, no. 1.View/Download from: Publisher's site
Li, JJ, Kim, K, Roohani-Esfahani, S-I, Guo, J, Kaplan, DL & Zreiqat, H 2015, 'A biphasic scaffold based on silk and bioactive ceramic with stratified properties for osteochondral tissue regeneration', JOURNAL OF MATERIALS CHEMISTRY B, vol. 3, no. 26, pp. 5361-5376.View/Download from: Publisher's site
Lu, Z, Roohani-Esfahani, S-I, Li, J & Zreiqat, H 2015, 'Synergistic effect of nanomaterials and BMP-2 signalling in inducing osteogenic differentiation of adipose tissue-derived mesenchymal stem cells', NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, vol. 11, no. 1, pp. 219-228.View/Download from: Publisher's site
Li, JJ, Kaplan, DL & Zreiqat, H 2014, 'Scaffold-based regeneration of skeletal tissues to meet clinical challenges', JOURNAL OF MATERIALS CHEMISTRY B, vol. 2, no. 42, pp. 7272-7306.View/Download from: Publisher's site
Roohani-Esfahani, S-I, Wong, KY, Lu, Z, Chen, YJ, Li, JJ, Gronthos, S, Menicanin, D, Shi, J, Dunstan, C & Zreiqat, H 2014, 'Fabrication of a novel triphasic and bioactive ceramic and evaluation of its in vitro and in vivo cytocompatibility and osteogenesis', JOURNAL OF MATERIALS CHEMISTRY B, vol. 2, no. 13, pp. 1866-1878.View/Download from: Publisher's site
Li, JJ, Gil, ES, Hayden, RS, Li, C, Roohani-Esfahani, S-I, Kaplan, DL & Zreiqat, H 2013, 'Multiple Silk Coatings on Biphasic Calcium Phosphate Scaffolds: Effect on Physical and Mechanical Properties and In Vitro Osteogenic Response of Human Mesenchymal Stem Cells', BIOMACROMOLECULES, vol. 14, no. 7, pp. 2179-2188.View/Download from: Publisher's site
Roohani-Esfahani, SI, Dunstan, CR, Li, JJ, Lu, Z, Davies, B, Pearce, S, Field, J, Williams, R & Zreiqat, H 2013, 'Unique microstructural design of ceramic scaffolds for bone regeneration under load', ACTA BIOMATERIALIA, vol. 9, no. 6, pp. 7014-7024.View/Download from: Publisher's site
Roohani-Esfahani, SI, Lu, ZF, Li, JJ, Ellis-Behnke, R, Kaplan, DL & Zreiqat, H 2012, 'Effect of self-assembled nanofibrous silk/polycaprolactone layer on the osteoconductivity and mechanical properties of biphasic calcium phosphate scaffolds', ACTA BIOMATERIALIA, vol. 8, no. 1, pp. 302-312.View/Download from: Publisher's site
© 2019 Elsevier Inc. All rights reserved. Biomaterials are the central element of biomedical engineering solutions to replace, restore, or improve the function of diseased or damaged tissues or organs. All biomaterials placed inside the body will elicit tissue responses, the nature and extent of which depend on the biocompatibility and bioactivity of the biomaterial. This article will introduce the sequence of tissue responses to biomaterials, including the inflammatory and wound healing responses and the foreign body reaction, followed by a summary of the influence of biomaterial characteristics on directing the tissue response to different classes of biomaterials.
- Kolling Institute, University of Sydney
- School of Biomedical Engineering, University of Sydney
- Peking University
- Shanghai Jiao Tong University
- Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences