Dr Javad Tavakoli moved to the University of Technology Sydney after being awarded the prestigious Chancellor's Postdoctoral Fellowship in January 2020. His PhD research at Flinders University mainly focused on understanding structure-function relationship in soft tissues that resulted in novel findings describing the ultrastructural organisation of elastic fibres in the intervertebral disc, for the first time. As a part of his PhD research, he developed a unique methodology for in-situ isolation and visualisation of the elastic fibres in the disc, significantly contributing to understanding the role of the elastic fibres during progression to herniation.
His previous postdoctoral research at Australia-China Joint Research Laboratory for Health Technologies led to the creation of new platforms for nano-fabrication and characterisation of hydrogels and cell tracking, using aggregation-induced-emission fluorogens and Vortex Fluidic Device. His knowledge in the design of drug delivery systems along with working experience in relevant industries resulted in the commercialisation of three products so far.
New and expanding areas of interest include the use of 3D bioprinting to engineer a novel 3D tissue for disc regeneration and performing mechanistic multiscale approaches to develop a toolbox for studying the clinical relevance of elastic fibres in both disc and other soft tissues to identify the relationship between elastic fibre disorders and tissue degeneration, ageing and deformity.
- Member of Centre for Health Technologies, University of Technology Sydney.
- Honorary appointment at Spine Services, Department of Orthopaedic Surgery, St. George Hospital, University of New South Wales.
- Member of Australian and New Zealand Orthopaedic Research Society (ANZORS).
- Member of Australian Nanotechnology Network (ANN).
- Honorary member of National Foundation of Elites, Technology Deputy of Iran Presidency Organization, Iran.
- Chancellor's Postdoctoral Fellowship, University of Technology Sydney, 2020.
- Spinal Research Award at the 30th Annual Scientific Meeting of the Spine Society of Australia, 2019.
- Acta Student Award Competition, Finalist for the best published research in Acta Biomaterialia journal, 2019.
- Clayton Adam Award for the Best ECR Scientific Paper Presentation at the 29th Annual Scientific Meeting of the Spine Society of Australia, 2018.
- Chancellor Award for the Best Higher Degree Research Student Publication, Flinders University, 2017.
- Outstanding Reviewer Award, Carbohydrate Polymers, Elsevier publication, 2017.
- Outstanding Reviewer Award, Materials Science and Engineering C, Elsevier publication, 2016.
- Dr. Ashtiyani Award for Iranian Young Scientists, National Foundation of Elites, Technology Deputy of Iran Presidency Organization, 2010.
- China Government Research Scholarships (CGS) for Early Career Researcher, 2019.
- Flinders University Research Higher Degree Scholarship, 2015- 2018.
- Top-Up PhD Scholarship,Depuy Synthes Inc (USA), 2016.
- Flinders University Summer Research Scholarship, 2015.
- Acta Biomaterialia
- Journal of Mechanical Behaviour of Biomedical Materials
- Materials Science and engineering:C
- Tissue Engineering and Regenerative Medicine
- Carbohydrate Polymers
Can supervise: YES
- Structure-function relationship in soft tissues
- Tissue engineering and 3D bioprinting
- Drug delivery systems
- Vortex-Fluidic Device for nanofabrication of biomaterials
- Functional wound dressings
- Drug delivery systems
Amin, DB, Tavakoli, J, Freeman, BJC & Costi, JJ 2020, 'Mechanisms of Failure Following Simulated Repetitive Lifting: A Clinically Relevant Biomechanical Cadaveric Study', Spine, vol. 45, no. 6, pp. 357-367.View/Download from: Publisher's site
© 2018 Wolters Kluwer Health, Inc. All rights reserved. Study Design.A biomechanical analysis correlating internal disc strains and tissue damage during simulated repetitive lifting.Objective.To understand the failure modes during simulated safe and unsafe repetitive lifting.Summary of Background Data.Repetitive lifting has been shown to lead to lumbar disc herniation (LDH). In vitro studies have developed a qualitative understanding of the effect of repetitive loading on LDH. However, no studies have measured internal disc strains and subsequently correlated these with disc damage.Methods.Thirty human cadaver lumbar functional spinal units were subjected to an equivalent of 1 year of simulated repetitive lifting under safe and unsafe levels of compression, in combination with flexion (13-15°), and right axial rotation (2°) for 20,000 cycles or until failure. Safe or unsafe lifting were applied as a compressive load to mimic holding a 20kg weight either close to, or at arm's length, from the body, respectively. Maximum shear strains (MSS) were measured, and disc damage scores were determined in nine regions from axial post-Test magnetic resonance imaging (MRI) and macroscopic images.Results.Twenty percent of specimens in the safe lifting group failed before 20,000 cycles due to endplate failure, compared with 67% in the unsafe group. Over half of the specimens in the safe lifting group failed via either disc protrusion or LDH, compared with only 20% via protrusion in the unsafe group. Significant positive correlations were found between MRI and macroscopic damage scores in all regions (rs>0.385, P<0.049). A significant positive correlation was observed in the left lateral region for MSS versus macroscopic damage score (rs=0.486, P<0.037) and MSS versus failure mode (rs=0.724, P=0.018, only specimens with disc failure). Pfirrmann Grade 3 discs were strongly associated with subsequent LDH (P=0.003).Conclusion.Increased shear strains were observed in the contralater...
Khorsand, M, Tavakoli, J, Guan, H & Tang, Y 2020, 'Artificial intelligence enhanced mathematical modeling on rotary triboelectric nanogenerators under various kinematic and geometric conditions', Nano Energy, vol. 75.View/Download from: Publisher's site
© 2020 Elsevier Ltd The triboelectric nanogenerator (TENG) has been introduced as a revolutionary technology in the renewable electrical energy generation at micro/nanoscale. In the current study, experimental and theoretical models for augmented rotary TENGs are presented. The power generated by TENGs is found to be a function of the number of segments, rotational speed, and tribo-surface spacing. Mathematical modeling combined with artificial intelligence is applied to characterize the TENG output under various kinematics and geometric conditions. Sensitivity analysis reveals that the generated energy and the matched resistance depend highly on segmentation and angular velocity rate. It is shown that the optimized harvested energy reaches 0.369 mJ at each cycle. The TENG dynamic outputs for various structural parameters are found and described. This study enhances understanding of rotation-induced periodic TENGs and reveals optimized characteristics for disk-shaped TENG energy harvesters.
Reza, AM, Tavakoli, J, Zhou, Y, Qin, J & Tang, Y 2020, 'Synthetic fluorescent probes to apprehend calcium signalling in lipid droplet accumulation in microalgae—an updated review', Science China Chemistry, vol. 63, no. 3, pp. 308-324.View/Download from: Publisher's site
© 2020, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature. Lipid bodies are dynamic organelles of photosynthetic microalgae that can be used as the third generation resources for biofuel production. Biosynthesis of lipids can be influenced by different signalling processes. Visualisation of these processes can provide useful information about the fate and associated roles of lipid molecules in different biological systems. In photosynthetic organisms, however, studies of calcium ediated lipid biosynthesis is bottlenecked due to the limitation of proper and efficient technologies, which also include visualisation techniques. Currently, most studies to visualise lipid droplets in vivo have used traditional dyes, and proper visualisation of lipid drops is hindered by dye-specific limitations. This hurdle could be overcome by using recently developed aggregation-induced emission biooprobes. This review reveals current knowledge gaps in the studies of lipid drops and calcium ions in microalgae, as calcium signaling is important secondary messenger to detect a wide variety of environmental stimuli in plant and animal cells. To obtain insight into the mechanisms of these processes, the merits and demerits of currently available visualisation techniques for lipid drops and calcium are also detailed. Finally, opportunities and possibilities are proposed to recommend further improvement of techniques for detecting the role of calcium during lipid formation in microalgae for biofuel production.
Tavakoli, J, Diwan, AD & Tipper, JL 2020, 'Advanced strategies for the regeneration of lumbar disc annulus fibrosus', International Journal of Molecular Sciences, vol. 21, no. 14, pp. 1-20.View/Download from: Publisher's site
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Damage to the annulus fibrosus (AF), the outer region of the intervertebral disc (IVD), results in an undesirable condition that may accelerate IVD degeneration causing low back pain. Despite intense research interest, attempts to regenerate the IVD have failed so far and no effective strategy has translated into a successful clinical outcome. Of particular significance, the failure of strategies to repair the AF has been a major drawback in the regeneration of IVD and nucleus replacement. It is unlikely to secure regenerative mediators (cells, genes, and biomolecules) and artificial nucleus materials after injection with an unsealed AF, as IVD is exposed to significant load and large deformation during daily activities. The AF defects strongly change the mechanical properties of the IVD and activate catabolic routes that are responsible for accelerating IVD degeneration. Therefore, there is a strong need to develop effective therapeutic strategies to prevent or reconstruct AF damage to support operational IVD regenerative strategies and nucleus replacement. By the way of this review, repair and regenerative strategies for AF reconstruction, their current status, challenges ahead, and future outlooks were discussed.
Tavakoli, J, Diwan, AD & Tipper, JL 2020, 'Elastic fibers: The missing key to improve engineering concepts for reconstruction of the Nucleus Pulposus in the intervertebral disc', Acta Biomaterialia.View/Download from: Publisher's site
© 2020 The increasing prevalence of low back pain has imposed a heavy economic burden on global healthcare systems. Intense research activities have been performed for the regeneration of the Nucleus Pulposus (NP) of the IVD; however, tissue-engineered scaffolds have failed to capture the multi-scale structural hierarchy of the native tissue. The current study revealed for the first time, that elastic fibers form a network across the NP consisting of straight and thick parallel fibers that were interconnected by wavy fine fibers and strands. Both straight fibers and twisted strands were regularly merged or branched to form a fine elastic network across the NP. As a key structural feature, ultrathin (53 ± 7 nm), thin (215 ± 20 nm), and thick (890 ± 12 nm) elastic fibers were observed in the NP. While our quantitative analysis for measurement of the thickness of elastic fibers revealed no significant differences (p < 0.633), the preferential orientation of fibers was found to be significantly different (p < 0.001) across the NP. The distribution of orientation for the elastic fibers in the NP represented one major organized angle of orientation except for the central NP. We found that the distribution of elastic fibers in the central NP was different from those located in the peripheral regions representing two symmetrically organized major peaks (±45⁰). No significant differences in the maximum fiber count at the major angles of orientation (±45⁰) were observed for both peripheral (p = 0.427) and central NP (p = 0.788). Based on these new findings a structural model for the elastic fibers in the NP was proposed. The geometrical presentation, along with the distribution of elastic fibers orientation, resulting from the present study identifies the ultrastructural organization of elastic fibers in the NP important towards understanding their mechanical role which is still under investigation. Given the results of this new geometrical analysis, more-accurate multisca...
Tavakoli, J, Diwan, AD & Tipper, JL 2020, 'The ultrastructural organization of elastic fibers at the interface of the nucleus and annulus of the intervertebral disk', Acta Biomaterialia.View/Download from: Publisher's site
© 2020 Acta Materialia Inc. There has been no study to describe the ultrastructural organization of elastic fibers at the interface of the nucleus pulposus and annulus fibrosus of the intervertebral disk (IVD), a region called the transition zone (TZ). A previously developed digestion technique was optimized to eliminate cells and non-elastin ECM components except for the elastic fibers from the anterolateral (AL) and posterolateral (PL) regions of the TZ in ovine IVDs. Not previously reported, the current study identified a complex elastic fiber network across the TZ for both AL and PL regions. In the AL region, this network consisted of major thick elastic fibers (≈ 1 µm) that were interconnected with delicate (< 200 nm) elastic fibers. While the same ultrastructural organization was observed in the PL region, interestingly the size of the elastic fibers was smaller (< 100 nm) compared to those that were located in the AL region. Quantitative analysis of the elastic fibers revealed significant differences in the size (p < 0.001) and the orientation of elastic fibers (p = 0.001) between the AL and PL regions, with a higher orientation and larger size of elastic fibers observed in the AL region. The gradual elimination of cells and non-elastin extracellular matrix components identified that elastic fibers in the TZ region in combination with the extracellular matrix created a honeycomb structure that was more compact at the AF interface compared to that located close to the NP. Three different symmetrically organized angles of rotation (0⁰ and ±90⁰) were detected for the honeycomb structure at both interfaces, and the structure was significantly orientated at the TZ-AF compared to the TZ-NP interface (p = 0.003).
Tavakoli, J, Pye, S, Reza, AHMM, Xie, N, Qin, J, Raston, CL, Tang, BZ & Tang, Y 2020, 'Tuning aggregation-induced emission nanoparticle properties under thin film formation', Materials Chemistry Frontiers, vol. 4, no. 2, pp. 537-545.View/Download from: Publisher's site
© 2020 the Partner Organisations. The most frequently used approach to preparing aggregation-induced emission fluorogen (AIEgen) particles is precipitation. Therefore, the addition of an AIEgen solution into water results in the formation of AIEgen particles in a very short time. Within such a short period of time and in the absence of proper mixing under shear, AIE particles are likely to be distributed in a wide range of sizes, thereby affecting their ultimate brightness and applications. Despite numerous attempts, the size of AIEgen particles is still within the range of 200-300 nm. For the first time, we developed a facile robust and cost-effective method for the fabrication of aggregation-induced emission nanoparticles with tuneable particle sizes <100 nm, high quantum yield, and excellent photostability. The direct diffusion of nanoparticles within the cell or in a single-celled organism, as an advantage of size reduction, opens new opportunities for biological and material studies. Such a significant reduction in AIE nanoparticle size has the potential for developing more efficient techniques for characterizing advanced nanomaterials and understanding biological processes and detection strategies.
Tavakoli, J, Raston, CL, Ma, Y & Tang, Y 2020, 'Vortex fluidic mediated one-step fabrication of polyvinyl alcohol hydrogel films with tunable surface morphologies and enhanced self-healing properties', Science China Materials, vol. 63, no. 7, pp. 1310-1317.View/Download from: Publisher's site
© 2020, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature. Previous strategies for controlling the surface morphologies of polyvinyl alcohol (PVA)-based hydrogels, including freeze-drying and electrospinning, require a post-treatment process, which can affect the final textures and properties of the hydrogels. Of particular interest, it is almost impossible to control the surface morphology during the formation of PVA hydrogels using these approaches. The strategy reported in this study used the novel vortex fluidic device (VFD) technology, which for the first time provided an opportunity for one-step fabrication of PVA hydrogel films. PVA hydrogels with different surface morphologies could be readily fabricated using a VFD. By also reducing the cross-linking agent concentration, a self-healing gel with enhanced fracture stress (60% greater than that of traditionally made hydrogel) was achieved. Interestingly, the associated self-healing property remained unchanged during the 260-s mechanical testing performed with the strain rate of 5% s−1. The VFD can effectively tune the surface morphologies of the PVA-based hydrogels and their associated properties, particularly the self-healing property.
Tavakoli, J, Wang, J, Chuah, C & Tang, Y 2020, 'Nartural-based hydrogels: A journey from simple to smart networks for medical examination', Current Medicinal Chemistry, vol. 27, no. 16, pp. 2704-2733.View/Download from: Publisher's site
© 2020 Bentham Science Publishers. Natural hydrogels, due to their unique biological properties, have been used extensively for various medical and clinical examinations that are performed to investigate the signs of disease. Re-cently, complex-crosslinking strategies improved the mechanical properties and advanced approaches have resulted in the introduction of naturally derived hydrogels that exhibit high biocompatibility, with shape memory and self-healing characteristics. Moreover, the creation of self-assembled natural hydro-gels under physiological conditions has provided the opportunity to engineer fine-tuning properties. To highlight recent studies of natural-based hydrogels and their applications for medical investigation, a critical review was undertaken using published papers from the Science Direct database. This review presents different natural-based hydrogels (natural, natural-synthetic hybrid and complex-crosslinked hydrogels), their historical evolution, and recent studies of medical examination applications. The application of natural-based hydrogels in the design and fabrication of biosensors, catheters and medical electrodes, detection of cancer, targeted delivery of imaging compounds (bioimaging) and fabrication of fluorescent bioprobes is summarised here. Without doubt, in future, more useful and practical con-cepts will be derived to identify natural-based hydrogels for a wide range of clinical examination appli-cations.
© 2019 Elsevier Ltd In light of the rapid growth in microelectronic technology, triboelectric nanogenerators (TENGs) have been exploited as securely sustainable substitutes for energy scavenging purposes as well as self-powered sensory utilization. In essence, TENGs' energy output and average power distribution depend highly on certain key parameters including contact area, the thickness of electric films and external resistance. This study attempts to predict the behavior of TENGs based on variation of those key parameters and tries to optimize the associated characteristics leading to high-output and light-weight sliding-mode TENGs. To meet this problem, an artificial intelligence approach is taken into consideration and solutions for load resistance and geometry are presented. Furthermore, an experimental setup is designed to evaluate the accuracy of the simulation results, demonstrating the precision of the applied theory. The results revealed that the predefined sliding-mode TENG can harvest 0.25 mJ at each cycle in an open-circuit condition where the weight is almost 42.91 g. Moreover, simulation proves that an appropriate value for the external resistor can increase the scavenged energy up to 3.65 mJ at each reciprocal movement. Finally, temporal responses for charge, current, voltage, power output, and harvested energy are plotted and discussed, facilitating understanding of the relationship between scavenged energy and optimized parameters.
Tavakoli, J, Laisak, E, Gao, M & Tang, Y 2019, 'AIEgen quantitatively monitoring the release of Ca2+ during swelling and degradation process in alginate hydrogels', Materials Science and Engineering C, vol. 104.View/Download from: Publisher's site
© 2019 Elsevier B.V. Alginate-based hydrogels are extensively used for different biomedical applications. While the swelling and degradation of alginate-based hydrogels affect their structure-property relationship, many studies employed gravimetric analysis to characterize the swelling-degradation process. Accurate or not, this traditional method is difficult to be consistently performed with minimized errors, especially at the late stage of the process. For the first time, this study introduced a reliable, accurate and cost-effective method to minimize the human-sourced errors during repetitive measurement of swelling and degradation of alginate-based hydrogels based on Ca2+ specified aggregation-induced emission fluorogen technology. This study provides an approach for characterization of different properties of alginate-based tissue engineered scaffolds. The established relation between the changes in released Ca2+ into the swelling environment and its relative intensity identified the potential application of the proposed method for prediction of swelling and degradation behaviour in alginate-based hydrogels.
Tavakoli, J, Zhang, HP, Tang, BZ & Tang, Y 2019, 'Aggregation-induced emission lights up the swelling process: A new technique for swelling characterisation of hydrogels', Materials Chemistry Frontiers, vol. 3, no. 4, pp. 664-667.View/Download from: Publisher's site
© 2019 the Partner Organisations. The characterization of the swelling properties in hydrogels suffers uncertainty due to the limitations that occur during weight change measurement. The current study successfully employed an aggregation-induced emission approach to suggest a new technique for the measurement of swelling properties in hydrogels. The changes in the fluorescence properties of the swelling environment reflect the swelling process.
Wang, J, Tavakoli, J & Tang, Y 2019, 'Bacterial cellulose production, properties and applications with different culture methods - A review.', Carbohydrate polymers, vol. 219, pp. 63-76.View/Download from: Publisher's site
Bacterial cellulose (BC) is an organic compound produced by certain types of bacteria. In natural habitats, the majority of bacteria synthesize extracellular polysaccharides, such as cellulose, which form protective envelopes around the cells. Many methods are currently being investigated to enhance cellulose growth. The various celluloses produced by different bacteria possess different morphologies, structures, properties, and applications. However, the literature lacks a comprehensive review of the different methods of BC production, which are critical to BC properties and their final applications. The aims of this review are to provide an overview of the production of BC from different culture methods, to analyze the characteristics of particular BC productions, to indicate existing problems associated with different methods, and to choose suitable culture approaches for BC applications in different fields. The main goals for future studies have also been discussed here.
Zhang, H-P, Han, W, Tavakoli, J, Zhang, Y-P, Lin, X, Lu, X, Ma, Y & Tang, Y 2019, 'Understanding interfacial interactions of polydopamine and glass fiber and their enhancement mechanisms in epoxy-based laminates', COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING, vol. 116, pp. 62-71.View/Download from: Publisher's site
Chuah, C, Wang, J, Tavakoli, J & Tang, Y 2018, 'Novel Bacterial Cellulose-Poly (Acrylic Acid) Hybrid Hydrogels with Controllable Antimicrobial Ability as Dressings for Chronic Wounds', POLYMERS, vol. 10, no. 12.View/Download from: Publisher's site
Han, W, Zhang, H-P, Tavakoli, J, Campbell, J & Tang, Y 2018, 'Polydopamine as sizing on carbon fiber surfaces for enhancement of epoxy laminated composites', COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING, vol. 107, pp. 626-632.View/Download from: Publisher's site
Tavakoli, J & Costi, JJ 2018, 'A method for visualization and isolation of elastic fibres in annulus fibrosus of the disc', MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol. 93, pp. 299-304.View/Download from: Publisher's site
Tavakoli, J & Costi, JJ 2018, 'New findings confirm the viscoelastic behaviour of the inter-lamellar matrix of the disc annulus fibrosus in radial and circumferential directions of loading', ACTA BIOMATERIALIA, vol. 71, pp. 411-419.View/Download from: Publisher's site
Tavakoli, J & Costi, JJ 2018, 'New insights into the viscoelastic and failure mechanical properties of the elastic fiber network of the inter-lamellar matrix in the annulus fibrosus of the disc', ACTA BIOMATERIALIA, vol. 77, pp. 292-300.View/Download from: Publisher's site
Tavakoli, J & Costi, JJ 2018, 'Ultrastructural organization of elastic fibres in the partition boundaries of the annulus fibrosus within the intervertebral disc', ACTA BIOMATERIALIA, vol. 68, pp. 67-77.View/Download from: Publisher's site
Tavakoli, J & Khosroshahi, ME 2018, 'Surface morphology characterization of laser-induced titanium implants: lesson to enhance osseointegration process', Biomedical Engineering Letters, vol. 8, no. 3, pp. 249-257.View/Download from: Publisher's site
© 2018, Korean Society of Medical and Biological Engineering and Springer-Verlag GmbH Germany, part of Springer Nature. The surface properties of implant are responsible to provide mechanical stability by creating an intimate bond between the bone and implant; hence, play a major role on osseointegration process. The current study was aimed to measure surface characteristics of titanium modified by a pulsed Nd:YAG laser. The results of this study revealed an optimum density of laser energy (140 Jcm−2), at which improvement of osteointegration process was seen. Significant differences were found between arithmetical mean height (Ra), root mean square deviation (Rq) and texture orientation, all were lower for 140 Jcm−2 samples compared to untreated one. Also it was identified that the surface segments were more uniformly distributed with a more Gaussian distribution for treated samples at 140 Jcm−2. The distribution of texture orientation at high laser density (250 and 300 Jcm−2) were approximately similar to untreated sample. The skewness index that indicates how peaks and valleys are distributed throughout the surface showed a positive value for laser treated samples, compared to untreated one. The surface characterization revealed that Kurtosis index, which tells us how high or flat the surface profile is, for treated sample at 140 Jcm−2 was marginally close to 3 indicating flat peaks and valleys in the surface profile.
Tavakoli, J, Amin, DB, Freeman, BJC & Costi, JJ 2018, 'The Biomechanics of the Inter-Lamellar Matrix and the Lamellae During Progression to Lumbar Disc Herniation: Which is the Weakest Structure?', ANNALS OF BIOMEDICAL ENGINEERING, vol. 46, no. 9, pp. 1280-1291.View/Download from: Publisher's site
Wang, J, Zhao, L, Zhang, A, Huang, Y, Tavakoli, J & Tang, Y 2018, 'Novel Bacterial Cellulose/Gelatin Hydrogels as 3D Scaffolds for Tumor Cell Culture', POLYMERS, vol. 10, no. 6.View/Download from: Publisher's site
Dehbari, N, Tavakoli, J, Khatraoab, SS & Tang, Y 2017, 'In situ polymerized hyperbranched polymer reinforced poly(acrylic acid) hydrogels', MATERIALS CHEMISTRY FRONTIERS, vol. 1, no. 10, pp. 1995-2004.View/Download from: Publisher's site
Dehbari, N, Tavakoli, J, Zhao, J & Tang, Y 2017, 'In situ formed internal water channels improving water swelling and mechanical properties of water swellable rubber composites', JOURNAL OF APPLIED POLYMER SCIENCE, vol. 134, no. 9.View/Download from: Publisher's site
Tavakoli, J 2017, 'Region-media coupling in characterization and modelling of the disc annulus single lamella swelling', MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, vol. 55, no. 8, pp. 1483-1492.View/Download from: Publisher's site
Tavakoli, J 2017, 'Tissue Engineering of the Intervertebral Disc's Annulus Fibrosus: A Scaffold-Based Review Study', TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 14, no. 2, pp. 81-91.View/Download from: Publisher's site
Tavakoli, J & Costi, JJ 2017, 'Development of a rapid matrix digestion technique for ultrastructural analysis of elastic fibers in the intervertebral disc', JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, vol. 71, pp. 175-183.View/Download from: Publisher's site
Tavakoli, J & Tang, Y 2017, 'Honey/PVA hybrid wound dressings with controlled release of antibiotics: Structural, physico-mechanical and in-vitro biomedical studies', MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol. 77, pp. 318-325.View/Download from: Publisher's site
Tavakoli, J, Elliott, DM & Costi, JJ 2017, 'The ultra-structural organization of the elastic network in the intra- and inter-lamellar matrix of the intervertebral disc', ACTA BIOMATERIALIA, vol. 58, pp. 269-277.View/Download from: Publisher's site
Tavaleoli, J 2017, 'Physico-mechanical, morphological and biomedical properties of a novel natural wound dressing material', JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, vol. 65, pp. 373-382.View/Download from: Publisher's site
Dehbari, N, Tavakoli, J, Zhao, J & Tang, Y 2016, 'Enhancing water swelling ability and mechanical properties of water-swellable rubber by PAA/SBS nanofiber mats', JOURNAL OF APPLIED POLYMER SCIENCE, vol. 133, no. 47.View/Download from: Publisher's site
Tavakoli, J, Elliott, DM & Costi, JJ 2016, 'Structure and Mechanical Function of the Inter-Lamellar Matrix of the Annulus Fibrosus in the Disc', JOURNAL OF ORTHOPAEDIC RESEARCH, vol. 34, no. 8, pp. 1307-1315.View/Download from: Publisher's site
Tavakoli, J, Miar, S, Zadehzare, MM & Akbari, H 2012, 'Evaluation of effectiveness of herbal medication in cancer care: A review study', Iranian Journal of Cancer Prevention, vol. 5, no. 3, pp. 144-156.
Based on a common belief, herbal medicine with the least possible side effects should be the center of attention in cancer care; however, in many cases they have not been properly studied with reliable clinical trials in human subjects. In this review, it was attempted to identify the available evidence on the use and clinical effects of herbs in cancer care. The research consists of two major parts including immunomodulator and chemopreventive herbal compounds whose mechanism, biological response, anticancer element of extract and related benefits were completely studied. Also, the safety of herbal anticancer compounds was discussed. Although the use of herbal medicines in treating cancer shows less chemotherapy-induced, toxicity, more researches are required to reach their full therapeutic potentials.
Khosroshahi, ME, Mahmoodi, M, Tavakoli, J & Tahriri, M 2008, 'Effect of Nd:Yttrium-aluminum-garnet laser radiation on Ti6Al4V alloy properties for biomedical applications', JOURNAL OF LASER APPLICATIONS, vol. 20, no. 4, pp. 209-217.View/Download from: Publisher's site
Jabbari, E, Tavakoli, J & Sarvestani, AS 2007, 'Swelling characteristics of acrylic acid polyelectrolyte hydrogel in a dc electric field', SMART MATERIALS AND STRUCTURES, vol. 16, no. 5, pp. 1614-1620.View/Download from: Publisher's site
Khosroshahi, ME, Mahmoodi, M & Tavakoli, J 2007, 'Characterization of Ti6A14V implant surface treated by Nd : YAG laser and emery paper for orthopaedic applications', APPLIED SURFACE SCIENCE, vol. 253, no. 21, pp. 8772-8781.View/Download from: Publisher's site
Khosroshahi, ME, Tavakoli, J & Mahmoodi, M 2007, 'Analysis of bioadhesivity of osteoblast cells on titanium alloy surface modified by Nd : YAG laser', JOURNAL OF ADHESION, vol. 83, no. 1-3, pp. 151-172.View/Download from: Publisher's site
Tavakoli, J, Khosroshahi, ME & Mahmoodi, M 2007, 'Characterization of Nd: YAG laser radiation effects on Ti6Al4V physico-chemical properties: An in vivo study', International Journal of Engineering, Transactions B: Applications, vol. 20, no. 1, pp. 1-11.
The effect of a Nd: YAG laser (1064 nm) has been studied on Ti6Al4V alloy in terms of optical and physical parameters for biomedical applications. The superior surface microhardness hardness (i.e. 377 VHN) is attributed to grain refinement associated with laser melting and rapid solidification. The electrochemical property, mainly pitting corrosion resistance, has been carried out in Hanks salt balanced physiological solution using standard potentiodynamic polarization testing. At the optimium laser treating fluence (140 Jcm -2), the EDX spectroscopy showed a decrease of about 30 % in the vanadium and the contact angle measurements also indicated an improved surface wettability seen in the characteristics with a contact angle of 35°. Finally, Cell spreading on the implanted specimens was analyzed by SEM and their condition in a specific area was studied for 10 cells for three separate regions on the same specimen using Image J Program software. The in vivo tests provided some useful clinical and pathological information regarding tissue response to the implants with different surface topography.
Tavakoli, J, Jabbari, E, Khosroshahi, ME & Boroujerdi, M 2006, 'Swelling characterization of anionic acrylic acid hydrogel in an external electric field', IRANIAN POLYMER JOURNAL, vol. 15, no. 11, pp. 891-900.
Khosroshahi, ME, Valanezhad, A & Tavakoli, J 2004, 'Evaluation of mid-IR laser radiation effect on 316L stainless steel corrosion resistance in physiological saline', Amirkabir (Journal of Science and Technology), vol. 15, no. 58 B, pp. 107-115.
The effects of a short pulsed (∼ 400 ns) multiline hydrogen fluoride (HF) laser radiation operating on average at 2.8 μm has been studied on 316L stainless steel in terms of optical and physical parameters. At low fluences ≤ 8 Jcm -2 (phase I) no morphological changes occurred at the surface and melting began at ∼ 8.8 Jcm -2 (phase II) which continued up to about 30 Jcm -2. In this range the melting zone was effectively produced by high temperature surface centres growth which subsequently joined these centres together. Thermal ablation via surface vaporization began at ∼ 33 Jcm -2 (phase III). The results of SEM evaluation and corrosion resistance experiment which was carried out using EG&G device with cyclic potentiodynamic polarization method in a physiological (Hank's) solution indicated that pitting corrosion sensitivity was decreased ie. enhancement of corrosion resistance. Also, the XRD results showed a double increase of γ(111) at microstructure, thus in effect a superaustenite stainless steel was obtained at an optimized melting fluence.
Javad, T, Yu, D & Youhong, T 2017, 'Biomedical polymer hybrid composites' in Hybrid Polymer Composite Materials, Elsevier, pp. 135-162.View/Download from: Publisher's site
Fathollahiopur, S, Maziarfar, S & Tavakoli, J 2013, 'Characterization and evaluation of acacia gum loaded PVA hybrid wound dressing', 2013 20th Iranian Conference on Biomedical Engineering, ICBME 2013, pp. 149-154.View/Download from: Publisher's site
Hydrogels based on natural polysaccharides are found to be so appealing for wound healing applications. The present study deals with the synthesis and characterization of PVA/acacia gum hybrid hydrogels where Arabic gum was evaluated as network properties improvement factor in hybrid hydrogel with the capability of antimicrobial agent (erythromycin) delivery in wound site. The comparison of drug release from mentioned hydrogel wound dressing with pure PVA hydrogel in stimulated wound fluid, swelling studies as a function of additive type, pH and temperature has been discussed. Eventually, the hybrid film was characterized by SEM. All of the observed results indicate that the hybrid hydrogel could easily be used as functional wound dressing to control the rate of antibiotic drug release to the wound site. © 2013 IEEE.
Boroojerdi, M, Setaredan, SK, Tavakoli, J & Mollaee, H 2008, 'Risk Management in Integrated Biomedical Engineering Preventive Maintenance Information Network', INTERNATIONAL SYMPOSIUM OF INFORMATION TECHNOLOGY 2008, VOLS 1-4, PROCEEDINGS, International Symposium on Information Technology, IEEE, Univ Kebangsaan, Fac Informat Sci & Technol, Kuala Lumpur, MALAYSIA, pp. 2443-+.
Boroojerdi, M, Setarehdan, SK & Tavakoli, J 2008, 'Evaluation of Water Conservation System for Sterilizer Cooling Mechanism: A Preventive Maintenance Study', INTERNATIONAL SYMPOSIUM OF INFORMATION TECHNOLOGY 2008, VOLS 1-4, PROCEEDINGS, International Symposium on Information Technology, IEEE, Univ Kebangsaan, Fac Informat Sci & Technol, Kuala Lumpur, MALAYSIA, pp. 2880-+.
Khosroshahi, ME, Enayati, M, Shafiei, S & Tavakoli, J 2007, 'Evaluation of drug release from PLGA nanospheres containing bethametasone', Progress in Biomedical Optics and Imaging - Proceedings of SPIE.
In this research poly (d,1-lactide-coglycolide acid) (PLGA) as polymeric nanospheres, polyvinyl alcohol) (PVA) with 87-89% hydrolysis degree as surfactant and distilled water as suspending medium were used. The encapsulated drug was Bethametasone. The nanospheres were prepared by an emulsion-solvent evaporation method. The nanospheres characterized by photon correlation spectroscopy (PCS) and scanning electron microscopy (SEM). The amount of drug release was determined by HPLC. In emulsion-solvent evaporation technique, time of ultrasound exposure, surfactant content in the formulation and evaporation rate of organic solvents were considered as formulation variables. © 2007 SPIE-OSA.
Khosroshahi, ME, Enayati, M, Shafiei, S & Tavakoli, J 2007, 'Evaluation of drug release from PLGA nanospheres containing bethametasone - art. no. 66331E', BIOPHOTONICS 2007: OPTICS IN LIFE SCIENCE, Biophotonics 2007 Conference, SPIE-INT SOC OPTICAL ENGINEERING, Munich, GERMANY, pp. E6331-E6331.View/Download from: Publisher's site
- Spine Services at Department of Orthopaedic Surgery, St. George Hospital, University of New South Wales.
- Australia-China Joint Research Centre for Personal Health Technology (ACJRC-PHT).
- Biomechanics and Implant Laboratory, Flinders University.