Dr Javad Tavakoli moved to the University of Technology Sydney after being awarded the prestigious Chancellor's Postdoctoral Fellowship in January 2020. His PhD research at Flinders University mainly focused on understanding structure-function relationship in soft tissues that resulted in novel findings describing the ultrastructural organisation of elastic fibres in the intervertebral disc, for the first time. As a part of his PhD research, he developed a unique methodology for in-situ isolation and visualisation of the elastic fibres in the disc, significantly contributing to understanding the role of the elastic fibres during progression to herniation.
His previous postdoctoral research at Australia-China Joint Research Laboratory for Health Technologies led to the creation of new platforms for nano-fabrication and characterisation of hydrogels and cell tracking, using aggregation-induced-emission fluorogens and Vortex Fluidic Device. His knowledge in the design of drug delivery systems along with working experience in relevant industries resulted in the commercialisation of three products so far.
New and expanding areas of interest include the use of 3D bioprinting to engineer a novel 3D tissue for disc regeneration and performing mechanistic multiscale approaches to develop a toolbox for studying the clinical relevance of elastic fibres in both disc and other soft tissues to identify the relationship between elastic fibre disorders and tissue degeneration, ageing and deformity.
- Member of Centre for Health Technologies, University of Technology Sydney.
- Honorary appointment at Spine Services, Department of Orthopaedic Surgery, St. George Hospital, University of New South Wales.
- Member of Australian and New Zealand Orthopaedic Research Society (ANZORS).
- Member of Australian Nanotechnology Network (ANN).
- Honorary member of National Foundation of Elites, Technology Deputy of Iran Presidency Organization, Iran.
- Chancellor's Postdoctoral Fellowship, University of Technology Sydney, 2020.
- Spinal Research Award at the 30th Annual Scientific Meeting of the Spine Society of Australia, 2019.
- Acta Student Award Competition, Finalist for the best published research in Acta Biomaterialia journal, 2019.
- Clayton Adam Award for the Best ECR Scientific Paper Presentation at the 29th Annual Scientific Meeting of the Spine Society of Australia, 2018.
- Chancellor Award for the Best Higher Degree Research Student Publication, Flinders University, 2017.
- Outstanding Reviewer Award, Carbohydrate Polymers, Elsevier publication, 2017.
- Outstanding Reviewer Award, Materials Science and Engineering C, Elsevier publication, 2016.
- Dr. Ashtiyani Award for Iranian Young Scientists, National Foundation of Elites, Technology Deputy of Iran Presidency Organization, 2010.
- China Government Research Scholarships (CGS) for Early Career Researcher, 2019.
- Flinders University Research Higher Degree Scholarship, 2015- 2018.
- Top-Up PhD Scholarship,Depuy Synthes Inc (USA), 2016.
- Flinders University Summer Research Scholarship, 2015.
- Acta Biomaterialia
- Journal of Mechanical Behaviour of Biomedical Materials
- Materials Science and engineering:C
- Tissue Engineering and Regenerative Medicine
- Carbohydrate Polymers
Can supervise: YES
- Structure-function relationship in soft tissues
- Tissue engineering and 3D bioprinting
- Drug delivery systems
- Vortex-Fluidic Device for nanofabrication of biomaterials
- Functional wound dressings
- Drug delivery systems
© 2019 Elsevier Ltd In light of the rapid growth in microelectronic technology, triboelectric nanogenerators (TENGs) have been exploited as securely sustainable substitutes for energy scavenging purposes as well as self-powered sensory utilization. In essence, TENGs’ energy output and average power distribution depend highly on certain key parameters including contact area, the thickness of electric films and external resistance. This study attempts to predict the behavior of TENGs based on variation of those key parameters and tries to optimize the associated characteristics leading to high-output and light-weight sliding-mode TENGs. To meet this problem, an artificial intelligence approach is taken into consideration and solutions for load resistance and geometry are presented. Furthermore, an experimental setup is designed to evaluate the accuracy of the simulation results, demonstrating the precision of the applied theory. The results revealed that the predefined sliding-mode TENG can harvest 0.25 mJ at each cycle in an open-circuit condition where the weight is almost 42.91 g. Moreover, simulation proves that an appropriate value for the external resistor can increase the scavenged energy up to 3.65 mJ at each reciprocal movement. Finally, temporal responses for charge, current, voltage, power output, and harvested energy are plotted and discussed, facilitating understanding of the relationship between scavenged energy and optimized parameters.
Tavakoli, J, Laisak, E, Gao, M & Tang, Y 2019, 'AIEgen quantitatively monitoring the release of Ca2+ during swelling and degradation process in alginate hydrogels', Materials Science and Engineering C, vol. 104.View/Download from: UTS OPUS or Publisher's site
© 2019 Elsevier B.V. Alginate-based hydrogels are extensively used for different biomedical applications. While the swelling and degradation of alginate-based hydrogels affect their structure-property relationship, many studies employed gravimetric analysis to characterize the swelling-degradation process. Accurate or not, this traditional method is difficult to be consistently performed with minimized errors, especially at the late stage of the process. For the first time, this study introduced a reliable, accurate and cost-effective method to minimize the human-sourced errors during repetitive measurement of swelling and degradation of alginate-based hydrogels based on Ca2+ specified aggregation-induced emission fluorogen technology. This study provides an approach for characterization of different properties of alginate-based tissue engineered scaffolds. The established relation between the changes in released Ca2+ into the swelling environment and its relative intensity identified the potential application of the proposed method for prediction of swelling and degradation behaviour in alginate-based hydrogels.
Tavakoli, J, Zhang, HP, Tang, BZ & Tang, Y 2019, 'Aggregation-induced emission lights up the swelling process: A new technique for swelling characterisation of hydrogels', Materials Chemistry Frontiers, vol. 3, no. 4, pp. 664-667.View/Download from: UTS OPUS or Publisher's site
© 2019 the Partner Organisations. The characterization of the swelling properties in hydrogels suffers uncertainty due to the limitations that occur during weight change measurement. The current study successfully employed an aggregation-induced emission approach to suggest a new technique for the measurement of swelling properties in hydrogels. The changes in the fluorescence properties of the swelling environment reflect the swelling process.
Wang, J, Tavakoli, J & Tang, Y 2019, 'Bacterial cellulose production, properties and applications with different culture methods - A review.', Carbohydrate polymers, vol. 219, pp. 63-76.View/Download from: UTS OPUS or Publisher's site
Bacterial cellulose (BC) is an organic compound produced by certain types of bacteria. In natural habitats, the majority of bacteria synthesize extracellular polysaccharides, such as cellulose, which form protective envelopes around the cells. Many methods are currently being investigated to enhance cellulose growth. The various celluloses produced by different bacteria possess different morphologies, structures, properties, and applications. However, the literature lacks a comprehensive review of the different methods of BC production, which are critical to BC properties and their final applications. The aims of this review are to provide an overview of the production of BC from different culture methods, to analyze the characteristics of particular BC productions, to indicate existing problems associated with different methods, and to choose suitable culture approaches for BC applications in different fields. The main goals for future studies have also been discussed here.
Zhang, H-P, Han, W, Tavakoli, J, Zhang, Y-P, Lin, X, Lu, X, Ma, Y & Tang, Y 2019, 'Understanding interfacial interactions of polydopamine and glass fiber and their enhancement mechanisms in epoxy-based laminates', COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING, vol. 116, pp. 62-71.View/Download from: Publisher's site
Chuah, C, Wang, J, Tavakoli, J & Tang, Y 2018, 'Novel Bacterial Cellulose-Poly (Acrylic Acid) Hybrid Hydrogels with Controllable Antimicrobial Ability as Dressings for Chronic Wounds', POLYMERS, vol. 10, no. 12.View/Download from: Publisher's site
Han, W, Zhang, H-P, Tavakoli, J, Campbell, J & Tang, Y 2018, 'Polydopamine as sizing on carbon fiber surfaces for enhancement of epoxy laminated composites', COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING, vol. 107, pp. 626-632.View/Download from: Publisher's site
Tavakoli, J & Costi, JJ 2018, 'A method for visualization and isolation of elastic fibres in annulus fibrosus of the disc', MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol. 93, pp. 299-304.View/Download from: Publisher's site
Tavakoli, J & Costi, JJ 2018, 'New findings confirm the viscoelastic behaviour of the inter-lamellar matrix of the disc annulus fibrosus in radial and circumferential directions of loading', ACTA BIOMATERIALIA, vol. 71, pp. 411-419.View/Download from: Publisher's site
Tavakoli, J & Costi, JJ 2018, 'New insights into the viscoelastic and failure mechanical properties of the elastic fiber network of the inter-lamellar matrix in the annulus fibrosus of the disc', ACTA BIOMATERIALIA, vol. 77, pp. 292-300.View/Download from: Publisher's site
Tavakoli, J & Costi, JJ 2018, 'Ultrastructural organization of elastic fibres in the partition boundaries of the annulus fibrosus within the intervertebral disc', ACTA BIOMATERIALIA, vol. 68, pp. 67-77.View/Download from: Publisher's site
Tavakoli, J & Khosroshahi, ME 2018, 'Surface morphology characterization of laser-induced titanium implants: lesson to enhance osseointegration process', Biomedical Engineering Letters, vol. 8, no. 3, pp. 249-257.View/Download from: Publisher's site
© 2018, Korean Society of Medical and Biological Engineering and Springer-Verlag GmbH Germany, part of Springer Nature. The surface properties of implant are responsible to provide mechanical stability by creating an intimate bond between the bone and implant; hence, play a major role on osseointegration process. The current study was aimed to measure surface characteristics of titanium modified by a pulsed Nd:YAG laser. The results of this study revealed an optimum density of laser energy (140 Jcm−2), at which improvement of osteointegration process was seen. Significant differences were found between arithmetical mean height (Ra), root mean square deviation (Rq) and texture orientation, all were lower for 140 Jcm−2 samples compared to untreated one. Also it was identified that the surface segments were more uniformly distributed with a more Gaussian distribution for treated samples at 140 Jcm−2. The distribution of texture orientation at high laser density (250 and 300 Jcm−2) were approximately similar to untreated sample. The skewness index that indicates how peaks and valleys are distributed throughout the surface showed a positive value for laser treated samples, compared to untreated one. The surface characterization revealed that Kurtosis index, which tells us how high or flat the surface profile is, for treated sample at 140 Jcm−2 was marginally close to 3 indicating flat peaks and valleys in the surface profile.
Tavakoli, J, Amin, DB, Freeman, BJC & Costi, JJ 2018, 'The Biomechanics of the Inter-Lamellar Matrix and the Lamellae During Progression to Lumbar Disc Herniation: Which is the Weakest Structure?', ANNALS OF BIOMEDICAL ENGINEERING, vol. 46, no. 9, pp. 1280-1291.View/Download from: Publisher's site
Wang, J, Zhao, L, Zhang, A, Huang, Y, Tavakoli, J & Tang, Y 2018, 'Novel Bacterial Cellulose/Gelatin Hydrogels as 3D Scaffolds for Tumor Cell Culture', POLYMERS, vol. 10, no. 6.View/Download from: Publisher's site
Dehbari, N, Tavakoli, J, Khatraoab, SS & Tang, Y 2017, 'In situ polymerized hyperbranched polymer reinforced poly(acrylic acid) hydrogels', MATERIALS CHEMISTRY FRONTIERS, vol. 1, no. 10, pp. 1995-2004.View/Download from: Publisher's site
Dehbari, N, Tavakoli, J, Zhao, J & Tang, Y 2017, 'In situ formed internal water channels improving water swelling and mechanical properties of water swellable rubber composites', JOURNAL OF APPLIED POLYMER SCIENCE, vol. 134, no. 9.View/Download from: Publisher's site
Tavakoli, J 2017, 'Region-media coupling in characterization and modelling of the disc annulus single lamella swelling', MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, vol. 55, no. 8, pp. 1483-1492.View/Download from: Publisher's site
Tavakoli, J 2017, 'Tissue Engineering of the Intervertebral Disc's Annulus Fibrosus: A Scaffold-Based Review Study', TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 14, no. 2, pp. 81-91.View/Download from: Publisher's site
Tavakoli, J & Costi, JJ 2017, 'Development of a rapid matrix digestion technique for ultrastructural analysis of elastic fibers in the intervertebral disc', JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, vol. 71, pp. 175-183.View/Download from: Publisher's site
Tavakoli, J & Tang, Y 2017, 'Honey/PVA hybrid wound dressings with controlled release of antibiotics: Structural, physico-mechanical and in-vitro biomedical studies', MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol. 77, pp. 318-325.View/Download from: Publisher's site
Tavakoli, J, Elliott, DM & Costi, JJ 2017, 'The ultra-structural organization of the elastic network in the intra- and inter-lamellar matrix of the intervertebral disc', ACTA BIOMATERIALIA, vol. 58, pp. 269-277.View/Download from: Publisher's site
Tavaleoli, J 2017, 'Physico-mechanical, morphological and biomedical properties of a novel natural wound dressing material', JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, vol. 65, pp. 373-382.View/Download from: Publisher's site
Dehbari, N, Tavakoli, J, Zhao, J & Tang, Y 2016, 'Enhancing water swelling ability and mechanical properties of water-swellable rubber by PAA/SBS nanofiber mats', JOURNAL OF APPLIED POLYMER SCIENCE, vol. 133, no. 47.View/Download from: Publisher's site
Tavakoli, J, Elliott, DM & Costi, JJ 2016, 'Structure and Mechanical Function of the Inter-Lamellar Matrix of the Annulus Fibrosus in the Disc', JOURNAL OF ORTHOPAEDIC RESEARCH, vol. 34, no. 8, pp. 1307-1315.View/Download from: Publisher's site
Tavakoli, J, Miar, S, Zadehzare, MM & Akbari, H 2012, 'Evaluation of effectiveness of herbal medication in cancer care: A review study', Iranian Journal of Cancer Prevention, vol. 5, no. 3, pp. 144-156.
Based on a common belief, herbal medicine with the least possible side effects should be the center of attention in cancer care; however, in many cases they have not been properly studied with reliable clinical trials in human subjects. In this review, it was attempted to identify the available evidence on the use and clinical effects of herbs in cancer care. The research consists of two major parts including immunomodulator and chemopreventive herbal compounds whose mechanism, biological response, anticancer element of extract and related benefits were completely studied. Also, the safety of herbal anticancer compounds was discussed. Although the use of herbal medicines in treating cancer shows less chemotherapy-induced, toxicity, more researches are required to reach their full therapeutic potentials.
Khosroshahi, ME, Mahmoodi, M, Tavakoli, J & Tahriri, M 2008, 'Effect of Nd:Yttrium-aluminum-garnet laser radiation on Ti6Al4V alloy properties for biomedical applications', JOURNAL OF LASER APPLICATIONS, vol. 20, no. 4, pp. 209-217.View/Download from: Publisher's site
Jabbari, E, Tavakoli, J & Sarvestani, AS 2007, 'Swelling characteristics of acrylic acid polyelectrolyte hydrogel in a dc electric field', SMART MATERIALS & STRUCTURES, vol. 16, no. 5, pp. 1614-1620.View/Download from: Publisher's site
Khosroshahi, ME, Mahmoodi, M & Tavakoli, J 2007, 'Characterization of Ti6A14V implant surface treated by Nd : YAG laser and emery paper for orthopaedic applications', APPLIED SURFACE SCIENCE, vol. 253, no. 21, pp. 8772-8781.View/Download from: Publisher's site
Khosroshahi, ME, Tavakoli, J & Mahmoodi, M 2007, 'Analysis of bioadhesivity of osteoblast cells on titanium alloy surface modified by Nd : YAG laser', JOURNAL OF ADHESION, vol. 83, no. 1-3, pp. 151-172.View/Download from: Publisher's site
Tavakoli, J, Khosroshahi, ME & Mahmoodi, M 2007, 'Characterization of Nd: YAG laser radiation effects on Ti6Al4V physico-chemical properties: An in vivo study', International Journal of Engineering, Transactions B: Applications, vol. 20, no. 1, pp. 1-11.
The effect of a Nd: YAG laser (1064 nm) has been studied on Ti6Al4V alloy in terms of optical and physical parameters for biomedical applications. The superior surface microhardness hardness (i.e. 377 VHN) is attributed to grain refinement associated with laser melting and rapid solidification. The electrochemical property, mainly pitting corrosion resistance, has been carried out in Hanks salt balanced physiological solution using standard potentiodynamic polarization testing. At the optimium laser treating fluence (140 Jcm -2), the EDX spectroscopy showed a decrease of about 30 % in the vanadium and the contact angle measurements also indicated an improved surface wettability seen in the characteristics with a contact angle of 35°. Finally, Cell spreading on the implanted specimens was analyzed by SEM and their condition in a specific area was studied for 10 cells for three separate regions on the same specimen using Image J Program software. The in vivo tests provided some useful clinical and pathological information regarding tissue response to the implants with different surface topography.
Tavakoli, J, Jabbari, E, Khosroshahi, ME & Boroujerdi, M 2006, 'Swelling characterization of anionic acrylic acid hydrogel in an external electric field', IRANIAN POLYMER JOURNAL, vol. 15, no. 11, pp. 891-900.
Khosroshahi, ME, Valanezhad, A & Tavakoli, J 2004, 'Evaluation of mid-IR laser radiation effect on 316L stainless steel corrosion resistance in physiological saline', Amirkabir (Journal of Science and Technology), vol. 15, no. 58 B, pp. 107-115.
The effects of a short pulsed (∼ 400 ns) multiline hydrogen fluoride (HF) laser radiation operating on average at 2.8 μm has been studied on 316L stainless steel in terms of optical and physical parameters. At low fluences ≤ 8 Jcm -2 (phase I) no morphological changes occurred at the surface and melting began at ∼ 8.8 Jcm -2 (phase II) which continued up to about 30 Jcm -2. In this range the melting zone was effectively produced by high temperature surface centres growth which subsequently joined these centres together. Thermal ablation via surface vaporization began at ∼ 33 Jcm -2 (phase III). The results of SEM evaluation and corrosion resistance experiment which was carried out using EG&G device with cyclic potentiodynamic polarization method in a physiological (Hank's) solution indicated that pitting corrosion sensitivity was decreased ie. enhancement of corrosion resistance. Also, the XRD results showed a double increase of γ(111) at microstructure, thus in effect a superaustenite stainless steel was obtained at an optimized melting fluence.
Javad, T, Yu, D & Youhong, T 2017, 'Biomedical polymer hybrid composites' in Hybrid Polymer Composite Materials, Elsevier, pp. 135-162.View/Download from: Publisher's site
Fathollahiopur, S, Maziarfar, S & Tavakoli, J 2013, 'Characterization and evaluation of acacia gum loaded PVA hybrid wound dressing', 2013 20th Iranian Conference on Biomedical Engineering, ICBME 2013, pp. 149-154.View/Download from: Publisher's site
Hydrogels based on natural polysaccharides are found to be so appealing for wound healing applications. The present study deals with the synthesis and characterization of PVA/acacia gum hybrid hydrogels where Arabic gum was evaluated as network properties improvement factor in hybrid hydrogel with the capability of antimicrobial agent (erythromycin) delivery in wound site. The comparison of drug release from mentioned hydrogel wound dressing with pure PVA hydrogel in stimulated wound fluid, swelling studies as a function of additive type, pH and temperature has been discussed. Eventually, the hybrid film was characterized by SEM. All of the observed results indicate that the hybrid hydrogel could easily be used as functional wound dressing to control the rate of antibiotic drug release to the wound site. © 2013 IEEE.
Boroojerdi, M, Setaredan, SK, Tavakoli, J & Mollaee, H 2008, 'Risk Management in Integrated Biomedical Engineering Preventive Maintenance Information Network', INTERNATIONAL SYMPOSIUM OF INFORMATION TECHNOLOGY 2008, VOLS 1-4, PROCEEDINGS, International Symposium on Information Technology, IEEE, Univ Kebangsaan, Fac Informat Sci & Technol, Kuala Lumpur, MALAYSIA, pp. 2443-+.
Boroojerdi, M, Setarehdan, SK & Tavakoli, J 2008, 'Evaluation of Water Conservation System for Sterilizer Cooling Mechanism: A Preventive Maintenance Study', INTERNATIONAL SYMPOSIUM OF INFORMATION TECHNOLOGY 2008, VOLS 1-4, PROCEEDINGS, International Symposium on Information Technology, IEEE, Univ Kebangsaan, Fac Informat Sci & Technol, Kuala Lumpur, MALAYSIA, pp. 2880-+.
Khosroshahi, ME, Enayati, M, Shafiei, S & Tavakoli, J 2007, 'Evaluation of drug release from PLGA nanospheres containing bethametasone', Progress in Biomedical Optics and Imaging - Proceedings of SPIE.
In this research poly (d,1-lactide-coglycolide acid) (PLGA) as polymeric nanospheres, polyvinyl alcohol) (PVA) with 87-89% hydrolysis degree as surfactant and distilled water as suspending medium were used. The encapsulated drug was Bethametasone. The nanospheres were prepared by an emulsion-solvent evaporation method. The nanospheres characterized by photon correlation spectroscopy (PCS) and scanning electron microscopy (SEM). The amount of drug release was determined by HPLC. In emulsion-solvent evaporation technique, time of ultrasound exposure, surfactant content in the formulation and evaporation rate of organic solvents were considered as formulation variables. © 2007 SPIE-OSA.
Khosroshahi, ME, Enayati, M, Shafiei, S & Tavakoli, J 2007, 'Evaluation of drug release from PLGA nanospheres containing bethametasone - art. no. 66331E', BIOPHOTONICS 2007: OPTICS IN LIFE SCIENCE, Biophotonics 2007 Conference, SPIE-INT SOC OPTICAL ENGINEERING, Munich, GERMANY, pp. E6331-E6331.View/Download from: Publisher's site
- Spine Services at Department of Orthopaedic Surgery, St. George Hospital, University of New South Wales.
- Australia-China Joint Research Centre for Personal Health Technology (ACJRC-PHT).
- Biomechanics and Implant Laboratory, Flinders University.