Dr Gungun Lin is an NHMRC Peter Doherty Early Career Fellow and the core member of the Institute for Biomedical Materials and Devices (IBMD) at the University of Technology Sydney. He is also a co-chief investigator of the ARC research hub for Integrated Devices for End-user Analysis at Low Levels (IDEAL). Before joining UTS, he obtained his Master Degree at the University of Ulm (Germany) and completed his PhD degree at the Leibniz Institute for Solid State and Materials Research Dresden (IFW Dresden e.V., Germany).
His research is in the area of Bio-MEMS (biomedical micro-electromechanical system) which deals with functional materials, mechanical parts and structures as well as advanced microfabrication technologies made suitable for biological and biomedical applications, with special focus on Magneto-MEMS. Most often, he uses microtechnology including vacuum deposition, lithography, and multiphase microfluidic approaches to build such systems, which allows the artful design, tailoring and investigation of their functionalities and magneto-physical/chemical effects. He applies these systems to address the key challenges in technology development for high-throughput screening, point-of-care testing, and deep characterisation of multiscale biological entities, with a bold vision of boosting healthcare efficiency.
He published as first author/leading corresponding author in top-tier journals, including Nature Nanotechnology, Advanced Materials, Chem, Small and Lab on a Chip. His works have been highlighted in journal cover pages such as Advanced Materials (2 x) , Small (1x), Lab on a Chip (2x) and Advanced Healthcare Materials (1x). His research has been recognised by several honours and awards, including the NHMRC Peter Doherty Australian Biomedical Engineering Fellowship in 2018, Ehrenfried Walther von Tschirnhaus Medal in 2017, Summa Cum Laude (the highest honour) for the doctoral dissertation, a prestigious Chinese Government Award for Outstanding Chinese Students Abroad.
Dr Gungun Lin manages the ARC-funded microfabrication and biomedical device characterisation facility at UTS.
Grants, Honours and Awards
- 2020-2022 ARC Research Hub for Integrated Devices for End-user Analysis at Low levels (IDEAL), co-chief investigator, (>$1M), Australian Research Council
- 2019-2022 NHMRC Early Career Fellowship, sole CI, ($320k), National Health and Medical Research Council
- 2018 Rising Star Award, Australian Association of Chinese Biomedical Scientists
- 2018 UTS Research Travel Fund ($3k), University of Technology Sydney
- 2017 the Ehrenfried Walther von Tschirnhaus Medal, Leibniz Institute for Solid State and Materials Research Dresden, Germany
- 2016 Summa Cum Laude for PhD thesis, Chemnitz University of Technology, Germany
- 2015 Chinese Government Prize for Outstanding Students Abroad, (USD $6000), China Scholarship Council
- 2009 Baden-württemberg Scholarship, Baden-Württemberg Stiftung, Germany
- 2008 He Yaoguang Prize, (¥10k), Southeast University Education Foundation, China
- 2008 Student Research Training Project (SRTP) Excellence, School of Materials Science and Engineering, Southeast University, China
- 2006 Excellent Student, Southeast University, China
- 2006 President Prize, (¥ 5k), Southeast University, China
Reviewing services for journals
- Advanced Materials, Advanced Materials Technologies, Advanced Intelligent System, AIP Advances, Biosensors and Bioelectronics, Applied Physics Letter, Biomicrofluidics, Journal of Micromechanics and Microengineering, Journal of Nanobiotechnology, Journal of Magnetism and Magnetic Materials, Light Sciences and Applications, Lab on Chip, Microfluidics and Nanofluidics, Micromachines, Nanoscale,Sensors and Actuators, RSC Advances,Scientific Reports, 2D Materials, and many more ...
- Reviewer board member of Micromachines (MDPI)
Reviewing services for grants
- NHMRC Ideas grant review panel since 2019
- NHMRC Development grant assessor Since 2020
Editorial services for journals
- Topic editor of Frontier in Mechanical Engineering
- Australian Nanotechnology Network
- International Society of Advanced Cytometry
- International Society for Extracellular Vesicles
Can supervise: YES
- Bio-MEMS/lab-on-a-chip technologies for point-of-care and high-throughput screening
- Functional intelligent/smart materials and micro- and nanosystems
- Micro- and nanorobots
- Biomedical polymers 42025 - Lecture on heterogeneous polymerizations
Huang, G, Lin, G, Zhu, Y, Duan, W & Jin, D 2020, 'Emerging technologies for profiling extracellular vesicle heterogeneity.', Lab on a chip, vol. 20, no. 14, pp. 2423-2437.View/Download from: Publisher's site
Extracellular vesicles (EVs) are membrane-bound vesicles secreted by most cell types and exist in virtually all bodily fluids. They carry on a wealth of proteomic and genetic information including proteins, lipids, miRNAs, mRNA, non-coding RNA and other molecules from parental cells. Increasing evidence shows that within populations of EVs, their biogenesis, physical characteristics (e.g. size, density, morphology) and cargos (e.g. protein, lipid content, nucleic acids) may vary substantially, which accordingly change their biological properties. To fully exploit the potential of EVs, it requires qualified methods to profile EV heterogeneity. In this review, we survey recent approaches for EV isolation with innovative discoveries in heterogeneity. The main challenges in EV heterogeneity research are identified, and the roles of single cell EV profiling and single EV imaging are highlighted. We further discuss promising opportunities for resolving the underlying complexity of EV heterogeneity.
Ren, W, Lin, G, Clarke, C, Zhou, J & Jin, D 2020, 'Optical Nanomaterials and Enabling Technologies for High-Security-Level Anticounterfeiting', ADVANCED MATERIALS, vol. 32, no. 18.View/Download from: Publisher's site
Fang, G, Lu, H, Law, A, Gallego-Ortega, D, Jin, D & Lin, G 2019, 'Gradient-sized control of tumor spheroids on a single chip', LAB ON A CHIP, vol. 19, no. 24, pp. 4093-4103.View/Download from: Publisher's site
Mi, C, Zhou, J, Wang, F, Lin, G & Jin, D 2019, 'Ultrasensitive Ratiometric Nanothermometer with Large Dynamic Range and Photostability', Chemistry of Materials, vol. 31, no. 22, pp. 9480-9487.View/Download from: Publisher's site
Copyright © 2019 American Chemical Society. Thermally responsive fluorescent nanoparticles can be constructed to allow robust, rapid, and noninvasive temperature measurements. Furthermore, due to their tiny size, they can be used to detect temperature changes at the nanoscale. In this way, such sensors are ideally suited to emerging applications including intracellular temperature sensing and microelectronics failure diagnostics. Despite their potential, current nanothermometers still suffer from limited sensitivity, dynamic range, and stability. By introducing thermal enhanced anti-Stokes emission from a pair of lanthanide ions, ytterbium and neodymium, we show an increase of more than 1 order of magnitude in both the sensitivity and the dynamic range when compared to conventional ytterbium and erbium-codoped nanothermometers. Here, we report heterogeneous temperature-responsive nanoparticles with a new record of sensitivity (9.6%/K at room temperature and above 2.3%/K at elevated temperatures up to 413 K) that can be used for ratiometric thermometry. The heterogeneous nanostructure design shows that the thermal responses can be fine-tuned by the controlled growth of nanoparticles. The stability of the ultrasensitive nanothermometers has enabled long-term noncontact monitoring of local heat dissipation of a microelectronic device.
He, H, Howard, CB, Chen, Y, Wen, S, Lin, G, Zhou, J, Thurecht, KJ & Jin, D 2018, 'Bispecific Antibody-Functionalized Upconversion Nanoprobe.', Analytical chemistry, vol. 90, no. 5, pp. 3024-3029.View/Download from: Publisher's site
Upconversion nanoparticles (UCNPs) are new optical probes for biological applications. For specific biomolecular recognition to be realized for diagnosis and imaging, the key lies in developing a stable and easy-to-use bioconjugation method for antibody modification. Current methods are not yet satisfactory regarding conjugation time, stability, and binding efficiency. Here, we report a facile and high-yield approach based on a bispecific antibody (BsAb) free of chemical reaction steps. One end of the BsAb is designed to recognize methoxy polyethylene glycol-coated UCNPs, and the other end of the BsAb is designed to recognize the cancer antigen biomarker. Through simple vortexing, BsAb-UCNP nanoprobes form within 30 min and show higher (up to 54%) association to the target than that of the traditional UCNP nanoprobes in the ELISA-like assay. We further demonstrate its successful binding to the cancer cells with high efficiency and specificity for background-free fluorescence imaging under near-infrared excitation. This method suggests a general approach broadly suitable for functionalizing a range of nanoparticles to specifically target biomolecules.
He, H, Liu, B, Wen, S, Liao, J, Lin, G, Zhou, J & Jin, D 2018, 'Quantitative Lateral Flow Strip Sensor Using Highly Doped Upconversion Nanoparticles.', Analytical chemistry, vol. 90, no. 21, pp. 12356-12360.View/Download from: Publisher's site
Paper-based lateral flow assays, though being low-cost and widely used for rapid in vitro diagnostics, are indicative and do not provide sufficient sensitivity for the detection and quantification of low abundant biomarkers for early stage cancer diagnosis. Here, we design a compact device to create a focused illumination spot with high irradiance, which activates a range of highly doped 50 nm upconversion nanoparticles (UCNPs) to produce orders of magnitude brighter emissions. The device employs a very low-cost laser diode, simplified excitation, and collection optics and permits a mobile phone camera to record the results. Using highly erbium ion (Er3+)-doped and thulium ion (Tm3+)-doped UCNPs as two independent reporters on two-color lateral flow strips, new records of limit of detection (LOD), 89 and 400 pg/mL, have been achieved for the ultrasensitive detection of prostate specific antigen (PSA) and ephrin type-A receptor 2 (EphA2) biomarkers, respectively, without crosstalk. The technique and device presented in this work suggests a broad scope of low-cost, rapid, and quantitative lateral flow assays in early detection of bioanalytes.
Ren, W, Zhou, Y, Lin, G, Wen, S, He, H, Liu, D & Jin, D 2018, 'DNA-mediated Anisotropic Silica Coating of Upconversion Nanoparticles', Chemical Communications, vol. 54, no. 52.View/Download from: Publisher's site
Ren, W, Wen, S, Tawfik, SA, Su, QP, Lin, G, Ju, LA, Ford, MJ, Ghodke, H, van Oijen, AM & Jin, D 2018, 'Anisotropic functionalization of upconversion nanoparticles.', Chemical science, vol. 9, no. 18, pp. 4352-4358.View/Download from: Publisher's site
Despite significant advances toward accurate tuning of the size and shape of colloidal nanoparticles, the precise control of the surface chemistry thereof remains a grand challenge. It is desirable to conjugate functional bio-molecules onto the selected facets of nanoparticles owing to the versatile capabilities rendered by the molecules. We report here facet-selective conjugation of DNA molecules onto upconversion nanoparticles via ligand competition reaction. Different binding strengths of phosphodiester bonds and phosphate groups on DNA and the surfactant molecules allow one to create heterogeneous bio-chemistry surface for upconversion nanoparticles. The tailored surface properties lead to the formation of distinct self-assembly structures. Our findings provide insight into the interactions between biomolecules and nanoparticles, unveiling the potential of using nanoparticles as fundamental building blocks for creating self-assembled nano-architectures.
Detection and quantification of a variety of micro- and nanoscale entities, e.g. molecules, cells, and particles, are crucial components of modern biomedical research, in which biosensing platform technologies play a vital role. Confronted with the drastic global demographic changes, future biomedical research entails continuous development of new-generation biosensing platforms targeting even lower costs, more compactness, and higher throughput, sensitivity and selectivity. Among a wide choice of fundamental biosensing principles, magnetic sensing technologies enabled by magnetic field sensors and magnetic particles offer attractive advantages. The key features of a magnetic sensing format include the use of commercially available magnetic field sensing elements, e.g. magnetoresistive sensors which bear huge potential for compact integration, a magnetic field sensing mechanism which is free from interference by complex biomedical samples, and an additional degree of freedom for the on-chip handling of biochemical species rendered by magnetic labels. In this review, we highlight the historical basis, routes, recent advances and applications of magnetic biosensing platform technologies based on magnetoresistive sensors.
Miao, S, He, S, Liang, M, Lin, G, Cai, B & Schmidt, OG 2017, 'Microtubular Fuel Cell with Ultrahigh Power Output per Footprint.', Advanced Materials, vol. 29, no. 34.View/Download from: Publisher's site
A novel realization of microtubular direct methanol fuel cells (µDMFC) with ultrahigh power output is reported by using "rolled-up" nanotechnology. The microtube (Pt-RuO2 -RUMT) is prepared by rolling up Ru2 O layers coated with magnetron-sputtered Pt nanoparticles (cat-NPs). The µDMFC is fabricated by embedding the tube in a fluidic cell. The footprint of per tube is as small as 1.5 × 10-4 cm2 . A power density of ≈257 mW cm-2 is obtained, which is three orders of magnitude higher than the present microsized DFMCs. Atomic layer deposition technique is applied to alleviate the methanol crossover as well as improve stability of the tube, sustaining electrolyte flow for days. A laminar flow driven mechanism is proposed, and the kinetics of the fuel oxidation depends on a linear-diffusion-controlled process. The electrocatalytic performance on anode and cathode is studied by scanning both sides of the tube wall as an ex situ working electrode, respectively. This prototype µDFMC is extremely interesting for integration with micro- and nanoelectronics systems.
Song, W, Lin, G, Ge, J, Fassbender, J & Makarov, D 2017, 'Encoding Microreactors with Droplet Chains in Microfluidics.', ACS Sensors, vol. 2, no. 12, pp. 1839-1846.View/Download from: Publisher's site
Droplet-based high throughput biomolecular screening and combinatorial synthesis entail a viable indexing strategy to be developed for the identification of each microreactor. Here, we propose a novel indexing scheme based on the generation of droplet sequences on demand to form unique encoding droplet chains in fluidic networks. These codes are represented by multiunit and multilevel droplets packages, with each code unit possessing several distinct signal levels, potentially allowing large encoding capacity. For proof of concept, we use magnetic nanoparticles as the encoding material and a giant magnetoresistance (GMR) sensor-based active sorting system supplemented with an optical detector to generate and decode the sequence of one exemplar sample droplet reactor and a 4-unit quaternary magnetic code. The indexing capacity offered by 4-unit multilevel codes with this indexing strategy is estimated to exceed 104, which holds great promise for large-scale droplet-based screening and synthesis.
Lin, G, Karnaushenko, DD, Bermudez, GSC, Schmidt, OG & Makarov, D 2016, 'Magnetic Suspension Array Technology: Controlled Synthesis and Screening in Microfluidic Networks', SMALL, vol. 12, no. 33, pp. 4553-4562.View/Download from: Publisher's site
Lin, G, Karnaushenko, DD, Bermúdez, GSC, Schmidt, OG & Makarov, D 2016, 'Droplet Microfluidics: Magnetic Suspension Array Technology: Controlled Synthesis and Screening in Microfluidic Networks (Small 33/2016)', Small, vol. 12, no. 33, p. 4580.View/Download from: Publisher's site
Karnaushenko, D, Ibarlucea, B, Lee, S, Lin, G, Baraban, L, Pregl, S, Melzer, M, Makarov, D, Weber, WM, Mikolajick, T, Schmidt, OG & Cuniberti, G 2015, 'Flexible Electronics: Light Weight and Flexible High-Performance Diagnostic Platform (Adv. Healthcare Mater. 10/2015)', Advanced Healthcare Materials, vol. 4, no. 10, pp. 1419-1419.View/Download from: Publisher's site
Karnaushenko, D, Ibarlucea, B, Lee, S, Lin, G, Baraban, L, Pregl, S, Melzer, M, Makarov, D, Weber, WM, Mikolajick, T, Schmidt, OG & Cuniberti, G 2015, 'Light Weight and Flexible High-Performance Diagnostic Platform', ADVANCED HEALTHCARE MATERIALS, vol. 4, no. 10, pp. 1517-1525.View/Download from: Publisher's site
Lin, G, Fomin, VM, Makarov, D & Schmidt, OG 2015, 'Supervised discriminant analysis for droplet micro-magnetofluidics', MICROFLUIDICS AND NANOFLUIDICS, vol. 19, no. 2, pp. 457-464.View/Download from: Publisher's site
Lin, G, Makarov, D & Schmidt, OG 2015, 'Strong Ferromagnetically-Coupled Spin Valve Sensor Devices for Droplet Magnetofluidics', SENSORS, vol. 15, no. 6, pp. 12526-12538.View/Download from: Publisher's site
Lin, G, Makarov, D, Medina-Sanchez, M, Guix, M, Baraban, L, Cuniberti, G & Schmidt, OG 2015, 'Magnetofluidic platform for multidimensional magnetic and optical barcoding of droplets', LAB ON A CHIP, vol. 15, no. 1, pp. 216-224.View/Download from: Publisher's site
Melzer, M, Karnaushenko, D, Lin, G, Baunack, S, Makarov, D & Schmidt, OG 2015, 'Direct Transfer of Magnetic Sensor Devices to Elastomeric Supports for Stretchable Electronics', ADVANCED MATERIALS, vol. 27, no. 8, pp. 1333-+.View/Download from: Publisher's site
Melzer, M, Karnaushenko, D, Lin, G, Baunack, S, Makarov, D & Schmidt, OG 2015, 'Stretchable Electronics: Direct Transfer of Magnetic Sensor Devices to Elastomeric Supports for Stretchable Electronics (Adv. Mater. 8/2015)', Advanced Materials, vol. 27, no. 8, pp. 1306-1306.View/Download from: Publisher's site
Streubel, R, Han, L, Im, M-Y, Kronast, F, Roessler, UK, Radu, F, Abrudan, R, Lin, G, Schmidt, OG, Fischer, P & Makarov, D 2015, 'Manipulating Topological States by Imprinting Non-Collinear Spin Textures', SCIENTIFIC REPORTS, vol. 5.View/Download from: Publisher's site
Lin, G, Makarov, D, Melzer, M, Si, W, Yan, C & Schmidt, OG 2014, 'A highly flexible and compact magnetoresistive analytic device', LAB ON A CHIP, vol. 14, no. 20, pp. 4050-4058.View/Download from: Publisher's site
Si, W, Moench, I, Yan, C, Deng, J, Li, S, Lin, G, Han, L, Mei, Y & Schmidt, OG 2014, 'A Single Rolled-Up Si Tube Battery for the Study of Electrochemical Kinetics, Electrical Conductivity, and Structural Integrity', ADVANCED MATERIALS, vol. 26, no. 47, pp. 7973-+.View/Download from: Publisher's site
Melzer, M, Lin, G, Makarov, D & Schmidt, OG 2012, 'Stretchable Spin Valves on Elastomer Membranes by Predetermined Periodic Fracture and Random Wrinkling', Advanced Materials, vol. 24, no. 48, pp. 6468-6472.View/Download from: Publisher's site
The first highly stretchable and sensitive spin valve sensor on elastomeric membranes are demonstrated. The sensor elements exhibit stable GMR behavior up to tensile strains of 29% in in situ stretching experiments and show no fatigue over 500 loading cycles. This remarkable stretchability is achieved by a predetermined periodic fracture mechanism that creates a meander-like pattern upon stretching.
Application fields such as smart skin1 and flexible or stretchable consumer electronics2–6 require a wide range of electronic components that are shapeable into nonplanar geometries after fabrication. Ideally, they should also be elastic and withstand many cycles of deformations without degrading in performance. Mechanical compliancy of thin films of naturally stiff materials can be achieved by different morphology transitions,6 that transfer large deformations of the substrate into small strains in the functional film, e.g., by wrinkling7, 8 or lithographically defined meander structures.9, 10 However, exploiting the full bandwidth and application potential of modern electronics requires implementation of stretchability into all types of electronic devices.
For instance, there is rapid progress in fabrication of interconnects11 and opto-electronic devices12 with stretchabilities up to several tens of percents. During the last years, magnetic13, 14 as well as magnetoresistive15–18 structures were fabricated and characterized on bendable polymeric substrates. Recently, stretchable magneto-electronics has been introduced by the fabrication of a wrinkled magnetic sensor based on [Co(Py)/Cu] multilayers19, 20 revealing a giant magnetoresistive (GMR) effect; Py stands for the permalloy, Ni81Fe19 alloy. However, only moderate stretchability of the magnetic sensor of up to about 4% was achieved. Furthermore, the sensitivity of stretchable magnetic sensors to small magnetic fields, as required for applications such as wearable electronics,1 has to be substantially enhanced....
Makarov, D, Melzer, M, Karnaushenko, D, Lin, G, Monch, I & Schmidt, OG 2015, 'Shapeable magnetic sensorics', 2015 IEEE International Magnetics Conference, INTERMAG 2015.View/Download from: Publisher's site
© 2015 IEEE. The flourishing and eagerness of portable consumer electronics necessitates functional elements to be lightweight, flexible, and even wearable (Figure 1) , fulfilling the needs of soft robotics, medical implants, imperceptible and transient electronics [2-4]. Next generation flexible appliances aim to become fully autonomous and will require ultra-thin and flexible navigation modules, body tracking and relative position monitoring systems. Key building blocks of navigation and position tracking devices are the magnetic field sensors.
Nickel, F, Gottlob, DM, Krug, IP, Doganay, H, Cramm, S, Kaiser, AM, Lin, G, Makarov, D, Schmidt, OG & Schneider, CM 2012, 'Time-resolved magnetic imaging in an aberration-corrected, energy-filtered photoemission electron microscope', ULTRAMICROSCOPY, 8th International Workshop on Low Energy Electron Microscopy and Photoemission Electron Microscopy (LEEM/PEEM), ELSEVIER SCIENCE BV, Hong Kong, PEOPLES R CHINA, pp. 54-62.View/Download from: Publisher's site
Minomic International Ltd. for prostate cancer diagnostics