Beth is a Senior Scientific Officer at UTS C3, providing support with bioinformatics, analytics, and software development.
Prior to joining C3, Beth completed a PhD in bioinformatics at the Garvan Institute in Sydney, focusing on developing computational methods for analysing RNA splicing.
Shah Mohammadi, N, Buapet, P, Pernice, M, Signal, B, Kahlke, T, Hardke, L & Ralph, PJ 2019, 'Transcriptome profiling analysis of the seagrass, Zostera muelleri under copper stress.', Marine pollution bulletin, vol. 149.View/Download from: Publisher's site
Copper (Cu) in an essential trace metal but it can also contaminate coastal waters at high concentrations mainly from agricultural run-off and mining activities which are detrimental to marine organisms including seagrasses. The molecular mechanisms driving Cu toxicity in seagrasses are not clearly understood yet. Here, we investigated the molecular responses of the Australian seagrass, Z. muelleri at the whole transcriptomic level after 7 days of exposure to 250 μg Cu L-1 and 500 μg Cu L-1. The leaf-specific whole transcriptome results showed a concentration-dependent disturbance in chloroplast function, regulatory stress responses and defense mechanisms. This study provided new insights into the responses of seagrasses to trace metal stress and reports possible candidate genes which can be considered as biomarkers to improve conservation and management of seagrass meadows.
Gloss, BS, Signal, B, Cheetham, SW, Gruhl, F, Kaczorowski, DC, Perkins, AC & Dinger, ME 2017, 'High resolution temporal transcriptomics of mouse embryoid body development reveals complex expression dynamics of coding and noncoding loci', Scientific reports, vol. 7, pp. 6731-6731.
Signal, B, Gloss, BS, Dinger, ME & Mercer, TR 2017, 'Machine learning annotation of human branchpoints', Bioinformatics, vol. 34, pp. 920-927.
Flynn, T, Signal, B, Johnson, SL & Gemmell, NJ 2016, 'Mitochondrial genome diversity among six laboratory zebrafish (Danio rerio) strains', MITOCHONDRIAL DNA PART A, vol. 27, no. 6, pp. 4364-4371.View/Download from: Publisher's site
Flynn, T, Signal, B, Johnson, SL & Gemmell, NJ 2016, 'Mitochondrial genome diversity among six laboratory zebrafish (Danio rerio) strains', Mitochondrial DNA Part A, vol. 27, pp. 4364-4371.
Gloss, BS, Signal, B, Cheetham, SW, Gruhl, F, Kaczorowski, D, Perkins, AC & Dinger, ME 2016, 'High temporal resolution of gene expression dynamics in developing mouse embryonic stem cells', bioRxiv, pp. 084442-084442.
Signal, B, Gloss, BS & Dinger, ME 2016, 'Computational approaches for functional prediction and characterisation of long noncoding RNAs', Trends in Genetics, vol. 32, pp. 620-637.
Signal, B, Gloss, BS, Dinger, ME & Mercer, TR 2016, 'Machine-learning annotation of human splicing branchpoints', BioRxiv, pp. 094003-094003.
Perdig ao, N, Heinrich, J, Stolte, C, Sabir, KS, Buckley, MJ, Tabor, B, Signal, B, Gloss, BS, Hammang, CJ, Rost, B & others 2015, 'Unexpected features of the dark proteome', Proceedings of the National Academy of Sciences, vol. 112, pp. 15898-15903.
Quek, XC, Thomson, DW, Maag, JLV, Bartonicek, N, Signal, B, Clark, MB, Gloss, BS & Dinger, ME 2014, 'lncRNAdb v2. 0: expanding the reference database for functional long noncoding RNAs', Nucleic acids research, vol. 43, pp. D168-D173.