Fine Dust Particle Mediated Airway Inflammation
$28,092 p.a. for three years, with the possibility of a 6 month extension.
The Centre for Inflammation currently has a full-time postgraduate scholarship available for a suitably qualified candidate with a strong Honours degree (or equivalent) in biomedical science, pharmacology, chemistry, biomedical engineering or pharmacy to undertake research studies leading to a PhD focused on fine dust particle mediated airway inflammation.
Air pollution is a primary risk factor associated with the induction and progression of chronic respiratory diseases. Major components of air pollutants are particulate matter (PM2.5 and PM10), carbon monoxide, carbon dioxide, elemental carbon, nitrogen dioxide, nitric oxide, black soot and sulfur dioxide. The bushfires in Australia every summer results in hazardous reductions in the level of air quality. Being very small in size, these fine dust particles reach deep into the lung during inhalation and induce airway inflammation. There are few studies that have assessed the deleterious effect of fine dust particles on respiratory health. This project will investigate their impact on the progression of airway inflammation and lung disease using an in vivo mouse model.
The key aims will be:
• Collection and characterization of ambient particulate matter (PM10) from various sites in NSW, Australia.
• Establishment of in vivo mouse models of airway inflammation induced by PM10 using a highly specialized InExposure system.
• Analysis of airway inflammations marker using molecular biology experiment techniques.
• Assessment of other disease features using established methods.
Who is eligible?
Applicants must be either permanent Australian residents or New Zealand citizens. To be eligible for this application, you must hold the following or equivalent degree in biomedical science, pharmacology, chemistry, biomedical engineering or pharmacy:
- Honours degree with First Class, or Second Class Division 1, or
- MSc Research or MSc Coursework with a research thesis of at least 6 months.
- be highly motivated and capable of independent work
- have a strong team focus
- possess excellent communication skills and the ability to work with a diverse range of people and within established collaborative teams
- have knowledge of a research/laboratory environment and requirements
- be computer literate in standard research software
- be able to maintain thorough laboratory records
- experience with standard lab techniques such as ELISA, RNA extraction, reverse transcription, qPCR, western blotting, cell culture, aseptic technique, histological analysis, Immunohistochemistry, Immunofluorescence, flow cytometry, and primer design.
- Be able to conduct in vivo mouse models