The PaCCSC Chief Investigator, Professor David Currow, provides leadership to the collaborative, supported by the National Manager, Linda Brown.
PaCCSC has a number of committees including a Trials Management Committee and study-specific Data and Safety Monitoring Committees.
Engagement with health professionals, researchers and the general community is a high priority for PaCCSC. We have a diverse national membership and encourage active participation in our research from colleagues and the community.
Data and Safety Monitoring Committee
Data and Safety Monitoring Committees (DSMCs) are independent contracted committees responsible for safety evaluation and determination, and reporting of adverse events for all studies conducted by PaCCSC.
DSMCs are external committees appointed independent of the management of PaCCSC.
Objectives and Responsibilities
- Responsible for the safety evaluations, determination and reporting of adverse events and the organisation and oversight of the monitoring and auditing of each study conducted under PaCCSC
- Ensures the services provided by PaCCSC are aligned with the principles of Good Clinical Practice (GCP)
- Operates in accordance with the Standard Operating Procedure for the DSMC established for each study
Trials Management Committee
The Trials Management Committee (TMC) is responsible for the development, review and oversight of issues specific to each study, including recruitment, outcomes and milestones.
The TMC has overall responsibility for the development, review and oversight of issues specific to the Palliative Care Clinical Studies Collaborative (PaCCSC) and Cancer Symptom Trials (CST) clinical research programs.
Objectives and responsibilities
- Be responsible for the oversight of the operationalisation of all study protocols approved by the PaCCSC Scientific Committee/CST Scientific Advisory Committee and monitor their associated key performance indicators throughout the trial life
- Provide a forum for new study ideas to be presented to the members
- To initiate individual Trial/Pilot Subcommittees as required and receive regular reports from study lead investigators
- To receive reports from the Joint Qualitative Research Subcommittee
- To initiate Trials Data Analysis Subcommittees if/when required to oversee the implementation of standardised measures and all statistical methodology and analysis
- Ensure all studies are conducted in line with the principles of Good Clinical Practice (GCP)
- To receive updates from members and/or participating sites on local research activities
Symptom node subcommittees
Symptom node subcommittees (SNSCs) are approved by the Trials Management Committee (TMC). SNSCs have oversight of all individual clinical research studies undertaken about their focus symptom. Read more on the research symptom nodes page.
Our membership structure encourages a broad selection of individuals with requisite skills, industry knowledge and palliative care experience to participate in PaCCSC activities and actively promote our research program.