Although warfarin is highly effective, its complex pharmacology has been associated with a greater...
Thesis Topic: Medicines for stroke prevention in atrial fibrillation: supporting decision-making
Supervisor: Associate Professor Beata Bajorek (School of Pharmacy, UTS)
The use of antithrombotic therapy (e.g., warfarin) to prevent stroke in elderly patients with atrial fibrillation (AF) is widely recognised. Although warfarin is highly effective, its complex pharmacology has been associated with a greater difficulty of use, leading to a potential increase in adverse events and/or reluctance by clinicians to prescribe it. To overcome these limitations, several novel oral anticoagulants (NOAC) have been developed and recently introduced into practice. The availability of these new anticoagulants for stroke prevention in AF has substantially expanded the treatment armamentarium, however, this has also rendered decision-making (regarding theselection of appropriate therapy) more complex. This research will develop and evaluate strategies to support decision-making in this clinical context.