In search of an Alzheimer’s cure
For decades, the field of Alzheimer's research has been dominated by a major hypothesis: that a build-up of beta amyloid (amyloid-β) in the brain causes Alzheimer's disease. However, despite years of research and billions of dollars spent on clinical trials, there is still no cure.
In a paper published in high-profile journal Acta Neuropathologica, researchers at the University of Technology Sydney outline evidence to question whether the emphasis on the amyloid hypothesis is preventing the development of alternative – and potentially disruptive – theories in Alzheimer's research.
"Over the last 30 years, the majority of tested therapeutics for Alzheimer's disease have been directed toward removing amyloid-β. Although we see merit in this strategy, we suggest that disease initiation and progression is more complex than can be accounted for by amyloid-β alone," says Professor of Neuroscience and Director of the UTS Centre for Neuroscience and Regenerative Medicine, Bryce Vissel.
Read the full story in the UTS Newsroom.